Protein: ATR
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)

Gene: ATR
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q13535

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000723 - telomere maintenance
GO:0003677 - DNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1109440

ATR
Serine/threonine-protein kinase ATR

6

17

Small-scale

0.935

High

1109525

PD1L1
Programmed cell death 1 ligand 1

3

13

High-throughput

0.861

High

262227

SCN2B
Sodium channel regulatory subunit beta-2

4

14

High-throughput

0.797

High

362281

ABL1
Tyrosine-protein kinase ABL1

2

4

Small-scale

0.792

High

1109454

CEA21
Cell adhesion molecule CEACAM21

3

3

High-throughput

0.770

High

1109489

VSIG2
V-set and immunoglobulin domain-containing protein 2

3

6

High-throughput

0.770

High

1109480

ATRIP
ATR-interacting protein

27

5

Small-scale

0.768

High

1109470

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

8

High-throughput

0.765

High

1109521

SCN3B
Sodium channel regulatory subunit beta-3

3

12

High-throughput

0.765

High

193267

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

163100

CHK1
Serine/threonine-protein kinase Chk1

10

4

Small-scale

0.752

High

799085

BRCA1
Breast cancer type 1 susceptibility protein

8

13

Small-scale

0.752

High

413782

P53
Cellular tumor antigen p53

8

7

Small-scale

0.750

High

1109496

CDC5L
Cell division cycle 5-like protein

1

2

Small-scale

0.747

High

1109481

TOPB1
DNA topoisomerase 2-binding protein 1

7

15

Small-scale

0.743

High

1102151

ATM
Serine-protein kinase ATM

2

18

Small-scale

0.738

High

298597

RAD17
Cell cycle checkpoint protein RAD17

6

6

Small-scale

0.729

High

580767

PVR
Poliovirus receptor

2

1

High-throughput

0.726

High

262074

NBN
Nibrin

5

6

Small-scale

0.726

High

842960

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

9

Small-scale

0.724

High

1109539

TELO2
Telomere length regulation protein TEL2 homolog

5

16

Small-scale

0.716

High

695390

RFA1
Replication protein A 70 kDa DNA-binding subunit

5

7

Small-scale

0.710

High

846600

MSH2
DNA mismatch repair protein Msh2

4

6

Small-scale

0.692

High

588632

RFA2
Replication protein A 32 kDa subunit

4

9

Small-scale

0.680

High

388185

GLPA
Glycophorin-A

3

3

High-throughput

0.662

High

484132

PGFRB
Platelet-derived growth factor receptor beta

3

16

High-throughput

0.662

High

1109450

RHEB
GTP-binding protein Rheb

1

14

Small-scale

0.648

High

1109524

DTL
Denticleless protein homolog

1

8

Small-scale

0.647

High

774339

BASI
Basigin

4

8

Small-scale

0.633

High

1109444

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

3

11

Small-scale

0.631

High

770853

OPRM
Mu-type opioid receptor

2

13

High-throughput

0.628

High

654109

XPA
DNA repair protein complementing XP-A cells

2

2

Small-scale

0.624

High

208045

TTI1
TELO2-interacting protein 1 homolog

2

16

Small-scale

0.621

High

754022

CD80
T-lymphocyte activation antigen CD80

1

14

High-throughput

0.618

High

1109452

CD226
CD226 antigen

1

13

High-throughput

0.618

High

976251

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.618

High

1109518

DCA13
DDB1- and CUL4-associated factor 13

1

4

Small-scale

0.618

High

332636

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.609

High

1109460

SCAR3
Scavenger receptor class A member 3

3

2

High-throughput

0.609

High

1109531

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.609

High

749327

TNFL8
Tumor necrosis factor ligand superfamily member 8

3

1

High-throughput

0.604

High

354971

CHK2
Serine/threonine-protein kinase Chk2

2

20

Small-scale

0.602

High

1109504

FACD2
Fanconi anemia group D2 protein

2

3

Small-scale

0.602

High

1109522

ETAA1
Ewing's tumor-associated antigen 1

2

0

Small-scale

0.598

High

1109491

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

9

Small-scale

0.595

High

1102527

MTA1
Metastasis-associated protein MTA1

2

3

Small-scale

0.584

High

487279

PARP1
Poly [ADP-ribose] polymerase 1

1

10

Small-scale

0.578

High

1109533

CE164
Centrosomal protein of 164 kDa

1

9

Small-scale

0.578

High

438076

GLPB
Glycophorin-B

2

3

High-throughput

0.574

High

622607

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

7

High-throughput

0.574

High

1109458

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

7

High-throughput

0.574

High

1109461

VASN
Vasorin

2

4

High-throughput

0.574

High

446990

NPM
Nucleophosmin

1

3

Small-scale

0.561

High

559344

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.561

High

896486

ETV1
ETS translocation variant 1

1

8

Small-scale

0.561

High

926348

BLM
RecQ-like DNA helicase BLM

1

11

Small-scale

0.561

High

1067286

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.561

High

1109453

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.561

High

1109499

CDC6
Cell division control protein 6 homolog

1

5

Small-scale

0.561

High

1109485

FBX32
F-box only protein 32

2

0

Small-scale

0.559

High

1109511

CLSPN
Claspin

2

0

Small-scale

0.559

High

897798

CDK9
Cyclin-dependent kinase 9

1

4

Small-scale

0.554

High

955138

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.553

High

1109512

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.553

High

593101

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

Small-scale

0.550

High

683238

TNR5
Tumor necrosis factor receptor superfamily member 5

2

7

High-throughput

0.549

High

1109541

NPTN
Neuroplastin

2

8

High-throughput

0.549

High

592720

LEUK
Leukosialin

1

1

High-throughput

0.536

High

599767

YBOX3
Y-box-binding protein 3

1

3

High-throughput

0.536

High

783573

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

14

High-throughput

0.536

High

854037

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

1109442

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1109467

PABP2
Polyadenylate-binding protein 2

1

4

High-throughput

0.536

High

1109479

HELQ
Helicase POLQ-like

1

2

Small-scale

0.536

High

1109482

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.536

High

1109486

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

5

High-throughput

0.536

High

1109490

OPALI
Opalin

1

3

High-throughput

0.536

High

1109502

CINP
Cyclin-dependent kinase 2-interacting protein

1

0

Small-scale

0.530

High

839003

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

11

Small-scale

0.527

High

1109542

NEMO
NF-kappa-B essential modulator

1

11

Small-scale

0.515

High

882481

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

1109472

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

127076

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.501

High

591637

H2AX
Histone H2AX

1

10

Small-scale

0.501

High

888041

MCM2
DNA replication licensing factor MCM2

1

9

Small-scale

0.501

High

1029079

E2F1
Transcription factor E2F1

1

4

Small-scale

0.501

High

1109474

MCPH1
Microcephalin

1

1

Small-scale

0.501

High

1109484

RENT1
Regulator of nonsense transcripts 1

1

8

Small-scale

0.501

High

1109494

DCR1C
Protein artemis

1

4

Small-scale

0.501

High

1109495

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

10

Small-scale

0.501

High

1109519

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.501

High

1109538

DCAF1
DDB1- and CUL4-associated factor 1

1

11

Small-scale

0.501

High

182527

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

209008

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.489

High

749200

CD70
CD70 antigen

1

1

High-throughput

0.489

High

914255

EFNA4
Ephrin-A4

1

5

High-throughput

0.489

High

914534

EFNA5
Ephrin-A5

1

5

High-throughput

0.489

High

1026019

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.489

High

1098892

KLRD1
Natural killer cells antigen CD94

1

5

High-throughput

0.489

High

1101481

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.489

High

1109446

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

1109466

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

2

High-throughput

0.489

High

1109473

LRC25
Leucine-rich repeat-containing protein 25

1

3

High-throughput

0.489

High

1109477

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

1109478

HUMMR
Protein MGARP

1

1

High-throughput

0.489

High

1109505

SEM4C
Semaphorin-4C

1

11

High-throughput

0.489

High

1109506

FXYD6
FXYD domain-containing ion transport regulator 6

1

1

High-throughput

0.489

High

1109507

F234A
Protein FAM234A

1

3

High-throughput

0.489

High

1109528

HCST
Hematopoietic cell signal transducer

1

3

High-throughput

0.489

High

1109530

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

1109537

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.489

High

1109540

GPR45
Probable G-protein coupled receptor 45

1

11

High-throughput

0.489

High

177865

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

19

Small-scale

0.481

High

187512

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.480

High

1109465

DPOLN
DNA polymerase nu

1

0

Small-scale

0.480

High

218155

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

231138

AIRE
Autoimmune regulator

1

13

Small-scale

0.479

High

241607

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

259910

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

293656

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

316844

MTA2
Metastasis-associated protein MTA2

1

3

Small-scale

0.479

High

363242

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.479

High

461448

HS90A
Heat shock protein HSP 90-alpha

1

13

Small-scale

0.479

High

567392

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

633316

MSH3
DNA mismatch repair protein Msh3

1

6

Small-scale

0.479

High

639376

5NTD
5'-nucleotidase

1

1

High-throughput

0.479

High

655813

TBG1
Tubulin gamma-1 chain

1

6

Small-scale

0.479

High

662574

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

6

Small-scale

0.479

High

756182

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.479

High

761669

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

768124

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

842746

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

8

Small-scale

0.479

High

913318

MSH6
DNA mismatch repair protein Msh6

1

7

Small-scale

0.479

High

916655

PPP5
Serine/threonine-protein phosphatase 5

1

13

Small-scale

0.479

High

928620

PMS1
PMS1 protein homolog 1

1

4

High-throughput

0.479

High

941429

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

979613

H4
Histone H4

1

6

High-throughput

0.479

High

998288

H31
Histone H3.1

1

10

Small-scale

0.479

High

1032808

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

1033673

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

1057605

CDK18
Cyclin-dependent kinase 18

1

2

Small-scale

0.479

High

1088829

TP53B
TP53-binding protein 1

1

5

High-throughput

0.479

High

1105909

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.479

High

1106827

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1109441

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

1109443

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1109445

SMC1A
Structural maintenance of chromosomes protein 1A

1

7

Small-scale

0.479

High

1109447

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

Small-scale

0.479

High

1109448

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1109451

NCOA2
Nuclear receptor coactivator 2

1

6

Small-scale

0.479

High

1109462

CDC73
Parafibromin

1

2

Small-scale

0.479

High

1109464

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1109471

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

9

Small-scale

0.479

High

1109476

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.479

High

1109492

NEK1
Serine/threonine-protein kinase Nek1

1

18

Small-scale

0.479

High

1109497

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1109500

RN126
E3 ubiquitin-protein ligase RNF126

1

4

Small-scale

0.479

High

1109503

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

16

High-throughput

0.479

High

1109513

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

Small-scale

0.479

High

1109516

ZDH18
Palmitoyltransferase ZDHHC18

1

3

High-throughput

0.479

High

1109527

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

1109449

PLEC
Plectin

1

5

High-throughput

0.470

High

253201

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

261719

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.458

High

341566

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.458

High

445863

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

1109459

INT3
Integrator complex subunit 3

1

0

Small-scale

0.458

High

1109498

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

1109501

TIPIN
TIMELESS-interacting protein

1

0

Small-scale

0.458

High

1109509

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.458

High

1109529

MUTYH
Adenine DNA glycosylase

1

0

Small-scale

0.458

High

380023

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.445

High

1109475

ZNT7
Zinc transporter 7

1

3

High-throughput

0.445

High

1109517

S39A9
Zinc transporter ZIP9

1

3

High-throughput

0.445

High

1109520

AATF
Protein AATF

1

1

Small-scale

0.445

High

1109535

RUVB1
RuvB-like 1

1

19

Small-scale

0.445

High

130089

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

895199

5HT6R
5-hydroxytryptamine receptor 6

1

7

Small-scale

0.437

High

1109463

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1109487

SPSB1
SPRY domain-containing SOCS box protein 1

1

11

Small-scale

0.437

High

1109488

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1109508

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1109523

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

6

High-throughput

0.437

High

1109536

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

6

Small-scale

0.437

High

1109493

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1109532

TIM
Protein timeless homolog

1

0

Small-scale

0.426

High

126105

AP3B1
AP-3 complex subunit beta-1

1

5

Small-scale

0.408

High

702949

DPOD1
DNA polymerase delta catalytic subunit

1

2

Small-scale

0.408

High

892678

DNLI4
DNA ligase 4

1

3

Small-scale

0.408

High

892862

MRE11
Double-strand break repair protein MRE11

1

6

Small-scale

0.408

High

904280

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.408

High

1083230

AP1B1
AP-1 complex subunit beta-1

1

5

Small-scale

0.408

High

1109457

E4F1
Transcription factor E4F1

1

3

Small-scale

0.408

High

1109514

RASF1
Ras association domain-containing protein 1

1

6

Small-scale

0.408

High

1109534

PA2G4
Proliferation-associated protein 2G4

1

2

Small-scale

0.408

High

166297

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.407

High

1109515

S22AB
Solute carrier family 22 member 11

1

3

High-throughput

0.407

High

1109483

ARHG1
Rho guanine nucleotide exchange factor 1

1

7

Small-scale

0.373

High

906048

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

0

High-throughput

0.347

High

916141

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.279

Low

1109455

F133B
Protein FAM133B

1

0

High-throughput

0.279

Low

1109456

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1109469

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1109526

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1109468

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low

1109510

NPAL2
NIPA-like protein 2

1

0

High-throughput

0.232

Low

1054177

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025