Protein: SMG1
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)

Gene: SMG1
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q96Q15

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1336159

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

Small-scale

0.801

High

1370068

RENT1
Regulator of nonsense transcripts 1

6

8

Small-scale

0.747

High

1400498

RBM8A
RNA-binding protein 8A

4

4

Small-scale

0.697

High

1400482

RENT2
Regulator of nonsense transcripts 2

5

0

Small-scale

0.694

High

1400479

SMG9
Nonsense-mediated mRNA decay factor SMG9

4

0

Small-scale

0.678

High

208079

TTI1
TELO2-interacting protein 1 homolog

3

16

Small-scale

0.671

High

807542

IF4A3
Eukaryotic initiation factor 4A-III

3

5

Small-scale

0.671

High

640267

EPHA1
Ephrin type-A receptor 1

3

7

High-throughput

0.662

High

1363949

SMG7
Nonsense-mediated mRNA decay factor SMG7

3

1

Small-scale

0.662

High

1400480

REN3A
Regulator of nonsense transcripts 3A

3

1

Small-scale

0.650

High

1400471

SMG1
Serine/threonine-protein kinase SMG1

1

17

Small-scale

0.647

High

961088

MGN
Protein mago nashi homolog

3

0

Small-scale

0.638

High

901502

RAB7A
Ras-related protein Rab-7a

1

8

High-throughput

0.618

High

1400472

REN3B
Regulator of nonsense transcripts 3B

2

1

Small-scale

0.611

High

1400496

TELO2
Telomere length regulation protein TEL2 homolog

2

16

Small-scale

0.611

High

388281

GLPA
Glycophorin-A

2

3

High-throughput

0.601

High

1124290

IF4A2
Eukaryotic initiation factor 4A-II

2

4

High-throughput

0.584

High

1310633

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

11

High-throughput

0.584

High

835735

KPCI
Protein kinase C iota type

1

14

Small-scale

0.573

High

976768

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

Small-scale

0.571

High

1400500

NPTN
Neuroplastin

2

8

High-throughput

0.549

High

550423

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.536

High

573629

ENPL
Endoplasmin

1

12

High-throughput

0.536

High

621941

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

Small-scale

0.536

High

854238

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

911657

NCBP2
Nuclear cap-binding protein subunit 2

1

5

Small-scale

0.536

High

977055

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.536

High

1314831

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

1

Small-scale

0.536

High

1400473

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

1400494

RUVB2
RuvB-like 2

1

19

Small-scale

0.536

High

1400495

RUVB1
RuvB-like 1

1

19

Small-scale

0.536

High

333391

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

262289

SCN2B
Sodium channel regulatory subunit beta-2

1

13

High-throughput

0.514

High

754081

CD80
T-lymphocyte activation antigen CD80

1

13

High-throughput

0.514

High

1293894

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

8

High-throughput

0.514

High

916111

NKX25
Homeobox protein Nkx-2.5

1

6

High-throughput

0.500

High

1400492

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

141626

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

213484

CTIF
CBP80/20-dependent translation initiation factor

1

1

High-throughput

0.479

High

242645

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

363737

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

404345

GCR
Glucocorticoid receptor

1

16

High-throughput

0.479

High

437309

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

461832

HS90A
Heat shock protein HSP 90-alpha

1

12

Small-scale

0.479

High

566011

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

581575

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

Small-scale

0.479

High

589456

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

630001

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

655894

TBG1
Tubulin gamma-1 chain

1

6

Small-scale

0.479

High

684363

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

761829

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

768936

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

791642

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

875757

PRC2A
Protein PRRC2A

1

5

High-throughput

0.479

High

900106

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.479

High

900469

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.479

High

1056916

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

1108059

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1252368

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1255137

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1259437

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.479

High

1275620

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

10

High-throughput

0.479

High

1280723

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

1288971

EST1A
Telomerase-binding protein EST1A

1

1

High-throughput

0.479

High

1329820

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

1336277

LS14A
Protein LSM14 homolog A

1

4

High-throughput

0.479

High

1370226

DAZL
Deleted in azoospermia-like

1

2

High-throughput

0.479

High

1400474

UNK
RING finger protein unkempt homolog

1

1

High-throughput

0.479

High

1400476

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.479

High

1400477

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.479

High

1400478

SIK2
Serine/threonine-protein kinase SIK2

1

5

Small-scale

0.479

High

1400483

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

1400489

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1400490

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1400493

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

1400497

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

1400501

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

5

High-throughput

0.479

High

967526

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

970048

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

985826

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

1400481

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1400485

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

1400488

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.458

High

1400475

NDEL1
Nuclear distribution protein nudE-like 1

1

4

High-throughput

0.457

High

129790

CBX4
E3 SUMO-protein ligase CBX4

1

3

High-throughput

0.445

High

250781

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

Small-scale

0.445

High

386125

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

Small-scale

0.445

High

409042

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

484206

PGFRB
Platelet-derived growth factor receptor beta

1

14

High-throughput

0.445

High

1366187

LPAR1
Lysophosphatidic acid receptor 1

1

7

High-throughput

0.445

High

1400484

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

895211

5HT6R
5-hydroxytryptamine receptor 6

1

7

Small-scale

0.437

High

1179706

LIN41
E3 ubiquitin-protein ligase TRIM71

1

13

Small-scale

0.437

High

1313804

S15A3
Solute carrier family 15 member 3

1

4

High-throughput

0.437

High

1336207

RN214
RING finger protein 214

1

2

High-throughput

0.437

High

1400486

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

50669

HACL2
2-hydroxyacyl-CoA lyase 2

1

3

High-throughput

0.407

High

104211

F5H1C8
Solute carrier family 15 member 3

1

4

High-throughput

0.407

High

437766

HEPS
Serine protease hepsin

1

4

High-throughput

0.407

High

683318

TNR5
Tumor necrosis factor receptor superfamily member 5

1

7

High-throughput

0.407

High

760772

CD68
Macrosialin

1

3

High-throughput

0.407

High

1219534

ANR22
Ankyrin repeat domain-containing protein 22

1

6

High-throughput

0.407

High

1400487

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.279

Low

1400491

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

1400499

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.249

Low

1350787

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025