HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 393
+	Hs
		437950 HS90B_HUMAN (1-724): 0: 1086: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (39-389): 6.73e-121: 360: 19.16
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (39-389): 7.59e-121: 360: 19.44
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Hs
		431598 HS90A_HUMAN (1-724): 0: 1072: 85.25		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (20-377): 5.52e-113: 340: 21.43
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (20-377): 7.89e-112: 337: 20.71
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (20-377): 7.89e-112: 337: 20.71
+	Hs
		131545 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK25_HUMAN (50-367): 4.36e-103: 312: 31.88
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45
+	Hs
		131544 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK25_HUMAN (50-367): 4.36e-103: 312: 31.88
+	Hs
		438128 HS90B_HUMAN (1-724): 0: 1086: 100.00		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		153070 HS90B_HUMAN (1-724): 0: 1086: 100.00		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49
+	Hs
		431636 HS90A_HUMAN (1-724): 0: 1072: 85.25		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		153069 HS90A_HUMAN (1-724): 0: 1072: 85.25		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49