HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M3K10 (Q02779)
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)
Gene: MAP3K10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 954
+	Hs
		438073 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77
+	Hs
		431735 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77
+	Hs
		438255 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59
+	Hs
		437966 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL2_HUMAN (5-935): 7.45e-135: 436: 17.33
+	Hs
		431626 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL2_HUMAN (5-935): 7.45e-135: 436: 17.33
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (5-950): 1.72e-126: 412: 18.02
+	Hs
		69196 HS90B_HUMAN (1-724): 0: 1086: 100.00		A9UEZ6_HUMAN (71-950): 6.37e-123: 411: 19.71
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (5-950): 1.72e-126: 412: 18.02
+	Hs
		438521 HS90B_HUMAN (1-724): 0: 1086: 100.00		TAOK3_HUMAN (80-807): 2.99e-120: 390: 16.30
+	Hs
		438113 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K12_HUMAN (80-836): 1e-119: 387: 27.17
+	Hs
		438348 HS90B_HUMAN (1-724): 0: 1086: 100.00		MINK1_HUMAN (98-925): 6.77e-114: 382: 16.47
+	Hs
		437847 HS90B_HUMAN (1-724): 0: 1086: 100.00		SRC_HUMAN (2-367): 1.64e-113: 361: 27.44
+	Hs
		411556 HS90B_HUMAN (1-724): 0: 1086: 100.00		LCK_HUMAN (2-372): 3.86e-113: 359: 25.00
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (38-417): 4.53e-106: 354: 28.17
+	Hs
		431481 HS90A_HUMAN (1-724): 0: 1072: 85.25		SRC_HUMAN (2-367): 1.64e-113: 361: 27.44
+	Hs
		411551 HS90A_HUMAN (1-724): 0: 1072: 85.25		LCK_HUMAN (2-372): 3.86e-113: 359: 25.00
+	Hs
		431561 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA2_HUMAN (38-417): 4.53e-106: 354: 28.17
+	Hs
		201182 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K7_HUMAN (83-355): 2.87e-45: 175: 38.49
+	Hs
		201181 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K7_HUMAN (83-355): 2.87e-45: 175: 38.49
+	Hs
		438211 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K11_HUMAN (579-916): 5.94e-11: 68.5: 17.01