Protein: HEAT3
HEAT repeat-containing protein 3 (Symportin Syo1) (hsSyo1)

Gene: HEAT3, HEATR3
Organism: Homo sapiens
Interactions: 190
UniProt ID: Q7Z4Q2

Gene Ontology (top 5):
GO:0006606 - protein import into nucleus
GO:0042273 - ribosomal large subunit biogenesis
GO:0043249 - erythrocyte maturation
GO:0051082 - unfolded protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1278620

TNPO1
Transportin-1

1

0

High-throughput

0.656

High

985741

RL11
Large ribosomal subunit protein uL5

3

0

High-throughput

0.634

High

262254

SCN2B
Sodium channel regulatory subunit beta-2

3

1

High-throughput

0.609

High

859339

RL5
Large ribosomal subunit protein uL18

2

0

High-throughput

0.602

High

438088

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

466929

ACM4
Muscarinic acetylcholine receptor M4

2

2

High-throughput

0.574

High

630169

ACM3
Muscarinic acetylcholine receptor M3

2

2

High-throughput

0.574

High

485232

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.553

High

171496

S27A2
Long-chain fatty acid transport protein 2

2

1

High-throughput

0.549

High

935904

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

1

High-throughput

0.549

High

1022895

EFNB1
Ephrin-B1

2

2

High-throughput

0.549

High

1103769

PLD1
Phospholipase D1

2

1

High-throughput

0.549

High

1179659

D19L1
Protein C-mannosyl-transferase DPY19L1

2

1

High-throughput

0.549

High

1113534

CUL3
Cullin-3

1

0

High-throughput

0.517

High

1181516

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

3

High-throughput

0.514

High

447164

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

1090451

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.513

High

210403

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

358728

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.489

High

388235

GLPA
Glycophorin-A

1

1

High-throughput

0.489

High

431175

LA
Lupus La protein

1

1

High-throughput

0.489

High

451016

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.489

High

666321

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.489

High

721027

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.489

High

828831

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

914287

EFNA4
Ephrin-A4

1

2

High-throughput

0.489

High

1062529

DHX9
ATP-dependent RNA helicase A

1

2

High-throughput

0.489

High

1096345

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

3

High-throughput

0.489

High

1101558

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1120220

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.489

High

1168832

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

High-throughput

0.489

High

1278634

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

2

High-throughput

0.489

High

1278636

YTDC2
3'-5' RNA helicase YTHDC2

1

2

High-throughput

0.489

High

728314

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

277371

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.437

High

939935

TPTE
Putative tyrosine-protein phosphatase TPTE

1

1

High-throughput

0.437

High

1164049

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.437

High

1194190

LARP7
La-related protein 7

1

2

High-throughput

0.437

High

1220602

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1209325

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

168863

PLD2
Phospholipase D2

1

1

High-throughput

0.407

High

210441

GPR39
G-protein coupled receptor 39

1

1

High-throughput

0.407

High

770805

HRH1
Histamine H1 receptor

1

2

High-throughput

0.407

High

914438

EFNB2
Ephrin-B2

1

2

High-throughput

0.407

High

1153405

CD226
CD226 antigen

1

1

High-throughput

0.407

High

1238870

D19L2
Probable C-mannosyltransferase DPY19L2

1

1

High-throughput

0.407

High

1240885

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.407

High

1278604

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

1

High-throughput

0.407

High

316520

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

4

0

High-throughput

0.360

High

845446

PE2R3
Prostaglandin E2 receptor EP3 subtype

4

0

High-throughput

0.360

High

1231119

SCAR3
Scavenger receptor class A member 3

4

0

High-throughput

0.360

High

1278603

CMTD1
Catechol O-methyltransferase domain-containing protein 1

4

0

High-throughput

0.360

High

1278621

TM186
Transmembrane protein 186

4

0

High-throughput

0.358

High

1089970

LMAN2
Vesicular integral-membrane protein VIP36

3

0

High-throughput

0.347

High

1149664

SURF2
Surfeit locus protein 2

3

0

High-throughput

0.347

High

1278618

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

640205

EPHA1
Ephrin type-A receptor 1

3

0

High-throughput

0.345

High

702798

5HT2C
5-hydroxytryptamine receptor 2C

3

0

High-throughput

0.345

High

749224

CD70
CD70 antigen

3

0

High-throughput

0.345

High

1278612

SIGL1
SIGLEC family-like protein 1

3

0

High-throughput

0.345

High

1278615

UXS1
UDP-glucuronic acid decarboxylase 1

3

0

High-throughput

0.345

High

1278637

PACC1
Proton-activated chloride channel

3

0

High-throughput

0.345

High

1278652

FZD10
Frizzled-10

3

0

High-throughput

0.345

High

363497

EGFR
Epidermal growth factor receptor

3

0

Small-scale

0.330

High

835311

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

0

High-throughput

0.328

High

332663

LYPD3
Ly6/PLAUR domain-containing protein 3

2

0

High-throughput

0.318

High

1278611

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.318

High

253860

TPST2
Protein-tyrosine sulfotransferase 2

2

0

High-throughput

0.313

High

911988

DGKE
Diacylglycerol kinase epsilon

2

0

High-throughput

0.313

High

1278280

LRP10
Low-density lipoprotein receptor-related protein 10

2

0

High-throughput

0.313

High

1278614

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.313

High

1278626

SEC62
Translocation protein SEC62

2

0

High-throughput

0.313

High

1278645

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.313

High

1278649

CC018
Uncharacterized protein C3orf18

2

0

High-throughput

0.313

High

1278654

EXOG
Nuclease EXOG, mitochondrial

2

0

High-throughput

0.313

High

1278623

DDRGK
DDRGK domain-containing protein 1

2

0

Small-scale

0.305

High

71223

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

221610

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.279

Low

223734

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

231237

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

257553

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

0

High-throughput

0.279

Low

279816

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.279

Low

322150

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.279

Low

328249

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

329297

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

337760

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

338882

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

348588

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.279

Low

405303

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

486583

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

522453

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.279

Low

532227

ESTD
S-formylglutathione hydrolase

1

0

High-throughput

0.279

Low

541107

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

565102

CSPG2
Versican core protein

1

0

High-throughput

0.279

Low

569322

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

0

High-throughput

0.279

Low

577984

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.279

Low

587352

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

1

0

High-throughput

0.279

Low

587713

DESP
Desmoplakin

1

0

High-throughput

0.279

Low

594035

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.279

Low

596196

H12
Histone H1.2

1

0

High-throughput

0.279

Low

617541

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

634125

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

634855

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.279

Low

640410

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

0

High-throughput

0.279

Low

641798

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.279

Low

722729

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.279

Low

760458

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

786154

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.279

Low

793724

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.279

Low

829444

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

869186

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

869905

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.279

Low

884146

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

914057

SPSY
Spermine synthase

1

0

High-throughput

0.279

Low

952501

CTXN1
Cortexin-1

1

0

High-throughput

0.279

Low

1029609

CD83
CD83 antigen

1

0

High-throughput

0.279

Low

1058109

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.279

Low

1100618

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.279

Low

1130317

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.279

Low

1136030

CND2
Condensin complex subunit 2

1

0

High-throughput

0.279

Low

1162661

THTR
Thiosulfate sulfurtransferase

1

0

High-throughput

0.279

Low

1199322

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.279

Low

1238238

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.279

Low

1238327

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

1

0

High-throughput

0.279

Low

1245248

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

0

High-throughput

0.279

Low

1249800

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1271976

CENPQ
Centromere protein Q

1

0

High-throughput

0.279

Low

1275462

TRM1L
tRNA

1

0

High-throughput

0.279

Low

1278017

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.279

Low

1278601

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.279

Low

1278602

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

1278606

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1278608

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

1278609

ASTRC
Protein Aster-C

1

0

High-throughput

0.279

Low

1278610

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.279

Low

1278613

KDM1B
Lysine-specific histone demethylase 2

1

0

High-throughput

0.279

Low

1278616

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1278617

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

1278622

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

1278624

DNJC1
DnaJ homolog subfamily C member 1

1

0

High-throughput

0.279

Low

1278625

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1278628

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.279

Low

1278630

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1278632

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1278633

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1278638

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

0

High-throughput

0.279

Low

1278640

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1278641

RBM28
RNA-binding protein 28

1

0

High-throughput

0.279

Low

1278644

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1278647

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.279

Low

1278648

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.279

Low

1278650

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.279

Low

1278651

ZN346
Zinc finger protein 346

1

0

High-throughput

0.279

Low

1278653

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.279

Low

1278656

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.279

Low

830986

CCNF
Cyclin-F

1

0

High-throughput

0.269

Low

1144388

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.269

Low

242132

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

315734

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

320709

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.249

Low

372424

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

589031

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

611195

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

695818

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768530

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1163365

CAH9
Carbonic anhydrase 9

1

0

Small-scale

0.249

Low

1248972

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1254419

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1271708

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1278631

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

1278635

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1278642

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1278646

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1278655

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.249

Low

1278657

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.249

Low

1278639

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

166335

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

185004

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.232

Low

194835

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.232

Low

430086

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

683273

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

965419

AP1S1
AP-1 complex subunit sigma-1A

1

0

High-throughput

0.232

Low

1199551

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

1278605

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

1278607

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.232

Low

1278619

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.232

Low

1278627

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1278629

TACAN
Transmembrane protein 120A

1

0

High-throughput

0.232

Low

1278643

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.232

Low

886992

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025