HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: NPAS1 (Q99742)
Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)
Gene: NPAS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 590
+	Hs
		438217 HS90B_HUMAN (1-724): 0: 1086: 100.00		HIF1A_HUMAN (29-579): 4.13e-145: 441: 26.97
+	Mm
		432431 HS90A_MOUSE (1-724): 0: 1068: 84.31		HIF1A_MOUSE (29-586): 2.22e-148: 450: 26.43
+	Hs
		431903 HS90A_HUMAN (1-724): 0: 1072: 85.25		HIF1A_HUMAN (29-579): 4.13e-145: 441: 26.97
+	Hs
		438165 HS90B_HUMAN (1-724): 0: 1086: 100.00		SIM2_HUMAN (47-583): 1.08e-134: 409: 30.73
+	Hs
		431844 HS90A_HUMAN (1-724): 0: 1072: 85.25		SIM2_HUMAN (47-583): 1.08e-134: 409: 30.73
+	Hs
		432201 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPAS1_HUMAN (32-585): 4.45e-128: 398: 22.74
+	Hs
		126097 HS90A_HUMAN (1-724): 0: 1072: 85.25		BMAL1_HUMAN (6-516): 5.72e-127: 388: 20.87
+	Hs
		431556 HS90A_HUMAN (1-724): 0: 1072: 85.25		ARNT_HUMAN (1-589): 1.34e-123: 384: 16.74
+	Hs
		431737 HS90A_HUMAN (1-724): 0: 1072: 85.25		SIM1_HUMAN (47-518): 1.38e-118: 371: 33.61
+	Mm
		432429 HS90A_MOUSE (1-724): 0: 1068: 84.31		SIM1_MOUSE (47-518): 8.41e-119: 371: 33.68
+	Mm
		513659 HS90B_MOUSE (1-724): 0: 1089: 99.59		AHR_MOUSE (50-525): 6.7e-103: 331: 22.72
+	Hs
		432385 HS90A_HUMAN (1-724): 0: 1072: 85.25		HIF3A_HUMAN (32-589): 1.16e-110: 347: 26.34
+	Hs
		431594 HS90A_HUMAN (1-724): 0: 1072: 85.25		AHR_HUMAN (50-525): 2.05e-104: 336: 22.42
+	Rn
		783943 HS90A_RAT (1-724): 0: 1070: 84.45		AHR_RAT (50-525): 2.16e-105: 338: 23.12
+	Mm
		432410 HS90A_MOUSE (1-724): 0: 1068: 84.31		AHR_MOUSE (50-525): 6.7e-103: 331: 22.72
+	Hs
		432199 HS90A_HUMAN (1-724): 0: 1072: 85.25		NPAS2_HUMAN (38-570): 1.76e-100: 324: 15.74
+	Dm
		1096504 Q9VAY2_DROME (4-692): 0: 848: 46.14		SIMA_DROME (23-559): 8.1e-107: 353: 25.86
+	Hs
		1050577 Q6PK50_HUMAN (1-350): 0: 618: 99.71		SIM2_HUMAN (47-583): 1.08e-134: 409: 30.73