Protein: EIF2A
Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]

Gene: EIF2A
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9BY44

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

624134

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

6

4

Small-scale

0.725

High

787707

SPB5
Serpin B5

3

5

High-throughput

0.667

High

387887

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

259087

DNJA2
DnaJ homolog subfamily A member 2

2

11

High-throughput

0.611

High

416043

CP1A1
Cytochrome P450 1A1

3

2

High-throughput

0.609

High

239195

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.602

High

725870

FGF9
Fibroblast growth factor 9

2

0

High-throughput

0.602

High

1417760

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

2

10

Small-scale

0.584

High

709010

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.574

High

1358194

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

396868

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1005060

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

Small-scale

0.561

High

245269

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

334235

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

362367

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.536

High

457671

TBB5
Tubulin beta chain

1

16

High-throughput

0.536

High

549674

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

611969

RL35A
Large ribosomal subunit protein eL33

1

4

High-throughput

0.536

High

727948

DNJA1
DnaJ homolog subfamily A member 1

1

11

High-throughput

0.536

High

1323924

KLH34
Kelch-like protein 34

1

2

High-throughput

0.536

High

1407549

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1417754

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1417767

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

373062

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.533

High

1327789

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

1417761

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.513

High

423087

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1417769

5MP1
eIF5-mimic protein 1

1

8

Small-scale

0.501

High

1416110

RBM4
RNA-binding protein 4

1

14

Small-scale

0.500

High

347298

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

783654

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

6

High-throughput

0.489

High

876157

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.489

High

1007252

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

1064594

HDHD1
Pseudouridine-5'-phosphatase

1

1

High-throughput

0.489

High

1144146

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.489

High

1148036

SF3B3
Splicing factor 3B subunit 3

1

9

High-throughput

0.489

High

1236111

FSTL4
Follistatin-related protein 4

1

5

High-throughput

0.489

High

1417755

DNAI2
Dynein axonemal intermediate chain 2

1

16

High-throughput

0.489

High

1270515

MARK2
Serine/threonine-protein kinase MARK2

1

0

Small-scale

0.480

High

227659

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.479

High

242816

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

346281

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

473047

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.479

High

537842

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

582942

EZRI
Ezrin

1

5

High-throughput

0.479

High

607075

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

766821

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

786822

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.479

High

791687

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

831372

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

954255

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

982804

RS24
Small ribosomal subunit protein eS24

1

4

High-throughput

0.479

High

1045726

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1067686

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1089845

ILF3
Interleukin enhancer-binding factor 3

1

11

Small-scale

0.479

High

1101009

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

1126529

CAPR1
Caprin-1

1

5

High-throughput

0.479

High

1131117

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

11

Small-scale

0.479

High

1156849

E2F4
Transcription factor E2F4

1

4

High-throughput

0.479

High

1161880

DUS5
Dual specificity protein phosphatase 5

1

1

High-throughput

0.479

High

1163185

H2B2E
Histone H2B type 2-E

1

7

High-throughput

0.479

High

1215805

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1255391

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1281605

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1334874

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1350439

BICD2
Protein bicaudal D homolog 2

1

7

High-throughput

0.479

High

1364577

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1383050

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1410822

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

8

Small-scale

0.479

High

1417753

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1417756

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

1417757

ANLN
Anillin

1

4

High-throughput

0.479

High

1417758

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1417762

E2AK4
eIF-2-alpha kinase GCN2

1

5

Small-scale

0.479

High

1417763

NXF1
Nuclear RNA export factor 1

1

2

Small-scale

0.479

High

1417764

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1417766

XPO7
Exportin-7

1

11

High-throughput

0.479

High

377717

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

556321

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

617246

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.458

High

354770

PAK4
Serine/threonine-protein kinase PAK 4

1

3

High-throughput

0.445

High

530331

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

658378

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.445

High

842851

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

7

High-throughput

0.445

High

1154922

NEDD8
Ubiquitin-like protein NEDD8

1

4

Small-scale

0.445

High

1209617

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1370089

RENT1
Regulator of nonsense transcripts 1

1

6

Small-scale

0.445

High

260408

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.437

High

352540

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

406599

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.437

High

412562

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

589604

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

643053

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

696417

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

769086

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

845989

DCC
Netrin receptor DCC

1

1

Small-scale

0.437

High

944162

WDR4
tRNA

1

17

Small-scale

0.437

High

1086901

CDC20
Cell division cycle protein 20 homolog

1

19

High-throughput

0.437

High

1092226

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.437

High

1100338

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.437

High

1138600

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.437

High

1155724

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.437

High

1226519

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

1227396

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.437

High

1276742

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1281058

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

1

Small-scale

0.437

High

1289597

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.437

High

1327176

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1338941

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.437

High

1417768

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.437

High

430322

JUN
Transcription factor Jun

1

13

High-throughput

0.407

High

1367189

ESR2
Estrogen receptor beta

1

20

High-throughput

0.407

High

887198

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.373

High

1381161

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

1404306

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

2

0

High-throughput

0.328

High

261550

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

296740

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1013333

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1391103

TRM61
tRNA

1

0

High-throughput

0.279

Low

1398201

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1417759

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

827481

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.265

Low

1417765

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025