HitPredict

Interactor 1: INHBA (P08476)
Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
Gene: INHBA

Interactor 2: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	9202237, 8389764, 10746731, 24018044, 8242742, 9605406
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0032924 - activin receptor signaling pathway GO:0045648 - positive regulation of erythrocyte differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 426 Hs			1 513
+	Mm
		646088 INHBA_MOUSE (1-426): 2.24e-167: 478: 96.01		AVR2A_MOUSE (1-513): 1.26e-154: 452: 99.61
+	Hs
		439886 INHBA_HUMAN (1-426): 6.69e-167: 477: 100.00		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		59851 A4D1W7_HUMAN (1-426): 6.69e-167: 477: 100.00		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Mm
		646092 INHBA_MOUSE (1-426): 2.24e-167: 478: 96.01		AVR2B_MOUSE (4-513): 1.8e-137: 409: 64.42
+	Hs
		439887 INHBA_HUMAN (1-426): 6.69e-167: 477: 100.00		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		439885 INHBA_HUMAN (1-426): 6.69e-167: 477: 100.00		ACVR1_HUMAN (47-493): 6.71e-117: 355: 30.27
+	Hs
		439882 INHBA_HUMAN (1-426): 6.69e-167: 477: 100.00		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41
+	Mm
		982854 INHBA_MOUSE (1-426): 2.24e-167: 478: 96.01		ACV1B_MOUSE (2-488): 1.87e-112: 344: 28.22
+	Hs
		439883 INHBA_HUMAN (1-426): 6.69e-167: 477: 100.00		ACVL1_HUMAN (42-490): 2.89e-106: 328: 29.38
+	Hs
		574181 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		451817 INHBB_HUMAN (31-426): 2.64e-106: 321: 41.35		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		574203 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		451820 INHBB_HUMAN (31-426): 2.64e-106: 321: 41.35		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		122282 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Hs
		574186 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41
+	Hs
		122280 BMP2_HUMAN (26-425): 1.11e-104: 317: 23.59		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Hs
		574204 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		451821 INHBB_HUMAN (31-426): 2.64e-106: 321: 41.35		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		574199 BMP7_HUMAN (48-425): 3.22e-108: 327: 19.46		ACVR1_HUMAN (47-493): 6.71e-117: 355: 30.27
+	Hs
		451818 INHBB_HUMAN (31-426): 2.64e-106: 321: 41.35		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41