HitPredict

Interactor 1: ODPA (P08559)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene: PDHA1

Interactor 2: PDK3 (Q15120)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
Gene: PDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	34079125, 28514442, 33961781, 27505672
Identification Methods	proximity labelling technology, affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 406
+	Hs
		669776 ODPAT_HUMAN (4-390): 2.34e-177: 500: 85.27		PDK3_HUMAN (1-406): 0: 642: 100.00
+	Hs
		440523 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Hs
		440524 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK2_HUMAN (1-405): 0: 602: 66.50
+	Hs
		440533 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK4_HUMAN (9-404): 0: 596: 63.13
+	Hs
		520709 ODBA_HUMAN (3-386): 4.22e-134: 392: 24.17		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Hs
		969481 ODO1_HUMAN (2-366): 2.85e-125: 387: 14.75		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Hs
		157284 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		BCKD_HUMAN (16-363): 4.88e-139: 404: 28.02
+	Hs
		157289 ODBA_HUMAN (3-386): 4.22e-134: 392: 24.17		BCKD_HUMAN (16-363): 4.88e-139: 404: 28.02
+	Sc
		558637 ODPA_YEAST (42-383): 1.18e-149: 431: 52.01		PDK1_YEAST (16-366): 5.67e-121: 358: 25.21