HitPredict

Interactor 1: CO4A2 (P08572)
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
Gene: COL4A2

Interactor 2: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0030198 - extracellular matrix organization GO:0035987 - endodermal cell differentiation GO:0062023 - collagen-containing extracellular matrix and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1712 Hs			1 707
+	Hs
		358650 CO4A1_HUMAN (665-1544): 3.39e-77: 286: 32.03		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		358595 CO2A1_HUMAN (2-439): 2.1e-46: 186: 29.23		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		436005 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		439220 CO4A2_HUMAN (1-1712): 0: 913: 100.00		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		540415 CO5A1_HUMAN (10-456): 7.6e-16: 86: 31.63		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		436002 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46
+	Hs
		372723 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		436012 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP8_HUMAN (35-295): 3.17e-81: 267: 32.01
+	Hs
		436025 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP16_HUMAN (45-280): 2.33e-72: 248: 32.35
+	Hs
		436022 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43
+	Hs
		436024 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP15_HUMAN (45-279): 2.87e-67: 235: 31.02
+	Hs
		358647 CO4A1_HUMAN (665-1544): 3.39e-77: 286: 32.03		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		439240 CO4A6_HUMAN (903-1546): 6.33e-52: 204: 27.18		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358587 CO2A1_HUMAN (2-439): 2.1e-46: 186: 29.23		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		436001 CO1A2_HUMAN (4-502): 7.66e-43: 174: 29.00		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358454 CO1A1_HUMAN (1022-1544): 2.38e-42: 172: 28.03		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358441 CO1A1_HUMAN (1022-1544): 2.38e-42: 172: 28.03		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80
+	Hs
		439227 CO5A1_HUMAN (10-456): 7.6e-16: 86: 31.63		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		362809 CO5A1_HUMAN (10-456): 7.6e-16: 86: 31.63		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80
+	Hs
		363093 CO7A1_HUMAN (1282-1560): 2.93e-11: 71: 27.24		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80