HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 654
+	Hs
		503944 RON_HUMAN (23-1390): 0: 934: 32.70		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		503499 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		501728 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		502130 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		503438 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		503517 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		564014 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		HSP76_HUMAN (25-635): 0: 915: 62.54
+	Hs
		502009 TYRO3_HUMAN (1053-1341): 6.19e-65: 240: 41.67		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		165150 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		435511 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		435510 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		411284 INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11		BIP_HUMAN (19-654): 0: 914: 100.00
+	Rn
		419257 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		BIP_RAT (1-654): 0: 918: 98.47
+	Rn
		544811 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		HSP7C_RAT (26-637): 0: 916: 66.02
+	Hs
		337324 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		503596 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		564025 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		HSP76_HUMAN (25-635): 0: 915: 62.54
+	Hs
		501787 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		BIP_HUMAN (19-654): 0: 914: 100.00