HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.80	0.746

Property	Details
Experiments	22789536, 18579758, 16537444
Identification Methods	cross-linking study, anti bait coimmunoprecipitation, phosphatase assay
Interaction Type	physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 435
+	Hs
		441433 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39
+	Hs
		441494 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		441487 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Mm
		56905 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRF_MOUSE (19-278): 5.35e-106: 346: 31.32
+	Mm
		554958 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRA_MOUSE (12-278): 2.85e-105: 332: 31.99
+	Hs
		441164 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		441507 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18
+	Hs
		441435 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43
+	Mm
		554962 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRK_MOUSE (6-279): 1.04e-61: 218: 25.18
+	Hs
		441515 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRO_HUMAN (20-274): 4.19e-48: 178: 38.31
+	Hs
		441488 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		441434 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		573629 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		725305 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		441184 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		872429 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		872635 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		985961 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		617082 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		850472 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18