HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	8662889, 9660480, 19433454, 21222362, 11063574
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 217
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		441500 MET_HUMAN (1-1390): 0: 1283: 100.00		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		441422 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		441462 MET_HUMAN (1-1390): 0: 1283: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433529 MET_HUMAN (1-1390): 0: 1283: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		441472 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		924497 RON_HUMAN (23-1390): 0: 934: 32.70		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		665389 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		337359 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412036 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412104 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433602 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522802 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58