Protein: AGAL
Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase)

Gene: AGAL, GLA
Organism: Homo sapiens
Interactions: 75
UniProt ID: P06280

Gene Ontology (top 5):
GO:0003824 - catalytic activity
GO:0004557 - alpha-galactosidase activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

441471

CALX
Calnexin

3

3

High-throughput

0.650

High

441511

FBX6
F-box only protein 6

3

2

High-throughput

0.633

High

441465

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.547

High

441502

SORT
Sortilin

1

0

Small-scale

0.545

High

188781

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

271342

DEPD5
GATOR1 complex protein DEPDC5

1

0

High-throughput

0.513

High

380244

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.513

High

441476

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

441483

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.513

High

441491

TM205
Transmembrane protein 205

1

0

High-throughput

0.513

High

441510

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.513

High

441520

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

441464

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

439613

INSR
Insulin receptor

1

3

High-throughput

0.500

High

441462

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.500

High

441481

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.500

High

217712

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

441463

MET
Hepatocyte growth factor receptor

1

4

High-throughput

0.479

High

441479

CUL3
Cullin-3

1

4

High-throughput

0.479

High

441484

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

441493

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

441509

RC3H2
Roquin-2

1

1

Small-scale

0.479

High

441512

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

162890

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

240492

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

293061

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

441470

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

441474

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

441482

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

441495

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

441496

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

441503

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.458

High

441507

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

441508

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.458

High

441514

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

441515

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.458

High

441519

CNOT6
CCR4-NOT transcription complex subunit 6

1

0

High-throughput

0.458

High

441477

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

5

High-throughput

0.457

High

441469

CMA1
Chymase

1

3

High-throughput

0.445

High

441473

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

441488

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.445

High

441490

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.445

High

441504

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

1

2

High-throughput

0.445

High

441513

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.445

High

441517

FBX2
F-box only protein 2

1

2

High-throughput

0.445

High

441461

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.437

High

441485

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

441506

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

167490

TX1B3
Tax1-binding protein 3

1

0

High-throughput

0.426

High

327734

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

332197

UCP5
Brain mitochondrial carrier protein 1

1

0

High-throughput

0.426

High

441466

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

Small-scale

0.426

High

441468

LEG3
Galectin-3

1

0

High-throughput

0.426

High

441475

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

Small-scale

0.426

High

441487

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.426

High

441494

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.426

High

441501

PCFT
Proton-coupled folate transporter

1

0

High-throughput

0.426

High

50080

S22AN
Solute carrier family 22 member 23

1

1

High-throughput

0.407

High

170617

CLGN
Calmegin

1

3

High-throughput

0.407

High

441480

ZNF79
Zinc finger protein 79

1

1

High-throughput

0.407

High

441489

ZFP1
Zinc finger protein 1 homolog

1

1

High-throughput

0.407

High

441498

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

2

High-throughput

0.407

High

441499

ZN764
Zinc finger protein 764

1

3

High-throughput

0.407

High

441500

ZN419
Zinc finger protein 419

1

1

High-throughput

0.407

High

441505

KLK15
Kallikrein-15

1

1

High-throughput

0.407

High

66862

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

441478

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

441497

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

185353

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

441467

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

441472

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

441492

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

441516

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

441518

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.249

Low

441486

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025