HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.706

Property	Details
Experiments	24728074, 18579758
Identification Methods	pull down, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 593
+	Hs
		441433 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		441494 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		441425 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Mm
		56905 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRF_MOUSE (33-522): 4.51e-112: 370: 25.45
+	Mm
		554958 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRA_MOUSE (33-522): 1.27e-110: 351: 23.52
+	Hs
		441164 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		441507 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94
+	Hs
		441434 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05
+	Mm
		554962 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRK_MOUSE (36-524): 2.79e-72: 254: 19.13
+	Hs
		872429 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		872635 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985961 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		609260 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		601501 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		573629 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		601466 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		725305 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		441184 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		617082 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05
+	Hs
		850472 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94