HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	9242692, 10871282, 10913131
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 694
+	Mm
		555049 MET_MOUSE (1-1381): 0: 1246: 89.57		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Mm
		101608 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		441588 MET_HUMAN (1-1390): 0: 1283: 100.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		981867 RON_HUMAN (23-1390): 0: 934: 32.70		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		57145 MET_MOUSE (1-1381): 0: 1246: 89.57		A2AI78_MOUSE (7-320): 1.74e-53: 200: 18.94
+	Hs
		872436 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872642 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665596 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872491 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		674415 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		435634 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665661 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1072602 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872492 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872712 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665662 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		1072603 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		609340 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13
+	Hs
		435765 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		674531 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49