HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29802200, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 551
+	Hs
		1084542 PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Mm
		857339 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62
+	Hs
		442310 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		1235752 PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1235838 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516635 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1119141 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PAP1L_HUMAN (81-485): 1.03e-19: 94.6: 12.53
+	Hs
		474021 PAB4L_HUMAN (7-182): 1.94e-24: 105: 13.56		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Sc
		376897 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Zm
		8143 A0A1D6ELH4_MAIZE (4-313): 2.89e-27: 116: 11.11		A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55
+	Hs
		442476 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Mm
		665745 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		PABP1_MOUSE (81-518): 3.65e-24: 108: 16.63
+	Sc
		376562 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96