Protein: RS21A
Small ribosomal subunit protein eS21A (40S ribosomal protein S21-A) (S26) (YS25)

Gene: RS21A, RPS21A
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: P0C0V8

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol
GO:0006412 - translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

502690

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.754

High

502706

RS2
Small ribosomal subunit protein uS5

2

3

High-throughput

0.754

High

502716

RSSA1
Small ribosomal subunit protein uS2A

2

15

High-throughput

0.754

High

502735

RIO2
Serine/threonine-protein kinase RIO2

5

5

Small-scale

0.709

High

502740

RSSA2
Small ribosomal subunit protein uS2B

1

15

High-throughput

0.618

High

149503

RS9A
Small ribosomal subunit protein uS4A

2

4

High-throughput

0.584

High

383434

RS17A
Small ribosomal subunit protein eS17A

2

2

High-throughput

0.584

High

392057

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.584

High

434714

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.584

High

435686

RS13
Small ribosomal subunit protein uS15

2

2

High-throughput

0.584

High

454786

RS19A
Small ribosomal subunit protein eS19A

2

4

High-throughput

0.584

High

502697

RS6A
Small ribosomal subunit protein eS6A

2

1

High-throughput

0.584

High

502698

RS8A
Small ribosomal subunit protein eS8A

2

3

High-throughput

0.584

High

502701

RS18A
Small ribosomal subunit protein uS13A

2

1

High-throughput

0.584

High

502707

KRR1
KRR1 small subunit processome component

2

1

Small-scale

0.584

High

502711

RS7A
Small ribosomal subunit protein eS7A

2

3

High-throughput

0.584

High

502717

RS3A1
Small ribosomal subunit protein eS1A

2

3

High-throughput

0.584

High

502719

RS27A
Small ribosomal subunit protein eS27A

2

3

High-throughput

0.584

High

502721

GBLP
Small ribosomal subunit protein RACK1

2

2

High-throughput

0.584

High

502722

ENP1
Essential nuclear protein 1

2

2

High-throughput

0.584

High

502723

RS20
Small ribosomal subunit protein uS10

2

1

High-throughput

0.584

High

502743

RS12
Small ribosomal subunit protein eS12

2

1

High-throughput

0.584

High

502747

RS15
Small ribosomal subunit protein uS19

2

1

High-throughput

0.584

High

502755

RS10A
Small ribosomal subunit protein eS10A

2

2

High-throughput

0.584

High

502718

LTV1
Protein LTV1

2

1

Small-scale

0.571

High

502734

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

502715

ZUO1
Zuotin

1

2

High-throughput

0.536

High

502745

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

435491

RS9B
Small ribosomal subunit protein uS4B

1

4

High-throughput

0.479

High

436266

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

441622

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

455352

RS19B
Small ribosomal subunit protein eS19B

1

4

High-throughput

0.479

High

502691

RS28B
Small ribosomal subunit protein eS28B

1

2

High-throughput

0.479

High

502692

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

502693

RS23B
Small ribosomal subunit protein uS12B

1

1

High-throughput

0.479

High

502694

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.479

High

502695

RS30A
Small ribosomal subunit protein eS30A

1

1

High-throughput

0.479

High

502696

RS4A
Small ribosomal subunit protein eS4A

1

2

High-throughput

0.479

High

502699

RS11B
Small ribosomal subunit protein uS17B

1

3

High-throughput

0.479

High

502700

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

502704

RS3A2
Small ribosomal subunit protein eS1B

1

3

High-throughput

0.479

High

502708

BUD23
18S rRNA

1

1

High-throughput

0.479

High

502709

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

502710

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

502731

RS26B
Small ribosomal subunit protein eS26B

1

3

High-throughput

0.479

High

502738

RS29A
Small ribosomal subunit protein uS14A

1

3

High-throughput

0.479

High

502739

RS29B
Small ribosomal subunit protein uS14B

1

3

High-throughput

0.479

High

502742

RS7B
Small ribosomal subunit protein eS7B

1

3

High-throughput

0.479

High

502749

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

502752

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

502754

TSR1
Ribosome biogenesis protein TSR1

1

2

High-throughput

0.479

High

502756

TMA46
Translation machinery-associated protein 46

1

2

High-throughput

0.479

High

502759

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

502764

RS25A
Small ribosomal subunit protein eS25A

1

2

High-throughput

0.479

High

409854

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

433362

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

502730

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

502737

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

502751

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

502763

RS21B
Small ribosomal subunit protein eS21B

1

0

High-throughput

0.458

High

502702

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

502760

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.439

High

438567

SC160
Protein SCP160

1

1

High-throughput

0.437

High

502705

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

502713

BMH1
Protein BMH1

1

1

High-throughput

0.437

High

502714

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.437

High

502724

OTU2
OTU domain-containing protein 2

1

1

High-throughput

0.437

High

502727

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.437

High

502728

STM1
Suppressor protein STM1

1

1

High-throughput

0.437

High

502733

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.437

High

502736

TM108
Protein TMA108

1

1

High-throughput

0.437

High

502741

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

502750

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

502753

TMA64
Translation machinery-associated protein 64

1

1

High-throughput

0.437

High

502761

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

502762

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

502703

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

502732

BIM1
Protein BIM1

1

1

High-throughput

0.407

High

502748

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.279

Low

502720

FRM2
nitroreductase FRM2

1

0

High-throughput

0.249

Low

502725

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.249

Low

502744

SLX9
Ribosome biogenesis protein SLX9

1

0

Small-scale

0.249

Low

502746

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.249

Low

502758

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

502712

BUD14
Bud site selection protein 14

1

0

High-throughput

0.232

Low

502726

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low

502729

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

502757

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025