Protein: RS21B
Small ribosomal subunit protein eS21B (40S ribosomal protein S21-B) (S26) (YS25)

Gene: RS21B, RPS21B
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: Q3E754

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol
GO:0006412 - translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

820411

RIO2
Serine/threonine-protein kinase RIO2

3

5

Small-scale

0.640

High

503320

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.618

High

674917

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.618

High

747665

RSSA1
Small ribosomal subunit protein uS2A

1

15

High-throughput

0.618

High

858099

RSSA2
Small ribosomal subunit protein uS2B

1

15

High-throughput

0.618

High

923168

BRE5
UBP3-associated protein BRE5

2

4

High-throughput

0.611

High

383970

RS17A
Small ribosomal subunit protein eS17A

2

2

Small-scale

0.571

High

150032

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

435465

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435655

RS9B
Small ribosomal subunit protein uS4B

1

4

High-throughput

0.479

High

436251

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

442194

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

455340

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

455457

RS19B
Small ribosomal subunit protein eS19B

1

4

High-throughput

0.479

High

502678

RS25B
Small ribosomal subunit protein eS25B

1

2

High-throughput

0.479

High

503532

RS28B
Small ribosomal subunit protein eS28B

1

2

High-throughput

0.479

High

504495

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

511709

RS23B
Small ribosomal subunit protein uS12B

1

1

High-throughput

0.479

High

511881

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.479

High

511975

RS30A
Small ribosomal subunit protein eS30A

1

1

High-throughput

0.479

High

512180

RS4A
Small ribosomal subunit protein eS4A

1

2

High-throughput

0.479

High

512735

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513302

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

513926

RS11B
Small ribosomal subunit protein uS17B

1

3

High-throughput

0.479

High

514207

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

514912

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

570325

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.479

High

655537

RS3A2
Small ribosomal subunit protein eS1B

1

3

High-throughput

0.479

High

677643

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

678259

BUD23
18S rRNA

1

1

High-throughput

0.479

High

680201

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

688965

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

689175

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

689743

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

753672

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

756706

LTV1
Protein LTV1

1

1

High-throughput

0.479

High

778612

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

792333

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

795623

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

798365

ENP1
Essential nuclear protein 1

1

2

High-throughput

0.479

High

802468

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

802750

RS27B
Small ribosomal subunit protein eS27B

1

3

High-throughput

0.479

High

812027

RS14B
Small ribosomal subunit protein uS11B

1

2

High-throughput

0.479

High

815397

RS26A
Small ribosomal subunit protein eS26A

1

3

High-throughput

0.479

High

815446

RS26B
Small ribosomal subunit protein eS26B

1

3

High-throughput

0.479

High

831872

RS29A
Small ribosomal subunit protein uS14A

1

3

High-throughput

0.479

High

831897

RS29B
Small ribosomal subunit protein uS14B

1

3

High-throughput

0.479

High

861051

RS10B
Small ribosomal subunit protein eS10B

1

2

High-throughput

0.479

High

870697

RS7B
Small ribosomal subunit protein eS7B

1

3

High-throughput

0.479

High

874612

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

918509

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

1033653

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1042287

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

1046337

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

1059262

TSR1
Ribosome biogenesis protein TSR1

1

2

High-throughput

0.479

High

1084083

TMA46
Translation machinery-associated protein 46

1

2

High-throughput

0.479

High

1084587

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

1185389

RS25A
Small ribosomal subunit protein eS25A

1

2

High-throughput

0.479

High

1185390

RS28A
Small ribosomal subunit protein eS28A

1

2

High-throughput

0.479

High

482110

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

502763

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.458

High

796898

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

844681

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

879909

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

1030625

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.458

High

1044871

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1065048

VTS1
RNA-binding protein VTS1

1

0

High-throughput

0.458

High

518168

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

865575

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

2

High-throughput

0.457

High

820231

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

438787

SC160
Protein SCP160

1

1

High-throughput

0.437

High

666575

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

732085

SYKM
Lysine--tRNA ligase, mitochondrial

1

1

High-throughput

0.437

High

752999

IXR1
Intrastrand cross-link recognition protein

1

1

Small-scale

0.437

High

789851

YC16
UPF0743 protein YCR087C-A

1

1

High-throughput

0.437

High

803286

OTU2
OTU domain-containing protein 2

1

1

High-throughput

0.437

High

807939

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.437

High

809451

STM1
Suppressor protein STM1

1

1

High-throughput

0.437

High

812145

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.437

High

817303

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.437

High

824963

TM108
Protein TMA108

1

1

High-throughput

0.437

High

865813

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

924947

NST1
Stress response protein NST1

1

2

High-throughput

0.437

High

1044531

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

1046109

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

1046876

TMA64
Translation machinery-associated protein 64

1

1

High-throughput

0.437

High

1064688

NAT5
N-alpha-acetyltransferase NAT5

1

1

High-throughput

0.437

High

692457

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

917418

SNT2
E3 ubiquitin-protein ligase SNT2

1

0

Small-scale

0.261

Low

402163

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

456558

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

0

High-throughput

0.249

Low

557654

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

High-throughput

0.249

Low

708652

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735246

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

780914

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.249

Low

818303

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

918744

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.249

Low

925437

FAP1
FKBP12-associated protein 1

1

0

High-throughput

0.249

Low

1031082

NOP3
Serine/arginine

1

0

High-throughput

0.249

Low

1054030

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1054886

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1056555

YL419
Putative ATP-dependent RNA helicase YLR419W

1

0

High-throughput

0.249

Low

1064313

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1065552

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1084501

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.249

Low

918281

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.238

Low

1038789

SKI8
Antiviral protein SKI8

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025