HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29802200
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 471
+	Hs
		1235752 PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		1235838 RBM7_HUMAN (96-357): 1.08e-35: 134: 18.73		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		442194 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1084542 PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Mm
		857339 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		CPSF6_MOUSE (1-451): 8.75e-77: 251: 39.51
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (83-184): 4.77e-13: 73.4: 19.61
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Dm
		1364315 Q9VE52_DROME (90-177): 5.87e-21: 96.4: 31.82		CPSF6_DROME (13-409): 3.19e-41: 157: 29.78
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Sc
		376897 RU17_YEAST (3-297): 9.1e-46: 162: 26.58		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		1119141 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PAP1L_HUMAN (73-164): 1.12e-12: 72.3: 19.57
+	Sc
		376562 PABP_YEAST (2-281): 3.47e-29: 121: 12.15		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		516635 PABP5_HUMAN (4-350): 4.45e-37: 141: 11.14		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Zm
		8143 A0A1D6ELH4_MAIZE (4-313): 2.89e-27: 116: 11.11		A0A1D6ELH4_MAIZE (53-167): 1.06e-09: 62.6: 20.87
+	Mm
		665745 TIA1_MOUSE (3-246): 4.89e-27: 113: 13.42		PABP1_MOUSE (73-165): 8.75e-10: 63: 19.36
+	Hs
		474021 PAB4L_HUMAN (7-182): 1.94e-24: 105: 13.56		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28