HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: FCGR1 (P12314)
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Gene: FCGR1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8064233
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 374
+	Mm
		435878 HCK_MOUSE (1-526): 0: 609: 89.54		FCGR1_MOUSE (11-372): 2.84e-71: 229: 65.01
+	Hs
		507818 SRC_HUMAN (1-524): 0: 582: 54.51		FGFR1_HUMAN (1-370): 2.07e-57: 201: 15.86
+	Hs
		433229 YES_HUMAN (1-524): 0: 570: 56.77		FGFR1_HUMAN (1-370): 2.07e-57: 201: 15.86
+	Hs
		519400 SRC_HUMAN (1-524): 0: 582: 54.51		FCERA_HUMAN (98-317): 7.3e-39: 141: 20.81
+	Hs
		411560 LCK_HUMAN (23-526): 0: 581: 64.89		FCG3A_HUMAN (99-322): 1.23e-33: 127: 15.79
+	Hs
		522812 SRC_HUMAN (1-524): 0: 582: 54.51		FCG2C_HUMAN (103-287): 3e-29: 117: 16.76
+	Hs
		522811 SRC_HUMAN (1-524): 0: 582: 54.51		FCG2B_HUMAN (103-287): 6.36e-29: 115: 16.76
+	Mm
		639452 LYN_MOUSE (22-526): 0: 555: 70.70		FCRL5_MOUSE (13-339): 1.46e-34: 136: 18.75
+	Hs
		412048 FYN_HUMAN (22-524): 0: 564: 57.79		FCG2C_HUMAN (103-287): 3e-29: 117: 16.76
+	Hs
		412047 FYN_HUMAN (22-524): 0: 564: 57.79		FCG2B_HUMAN (103-287): 6.36e-29: 115: 16.76
+	Hs
		433545 LYN_HUMAN (22-526): 0: 554: 70.70		FCG2A_HUMAN (103-290): 5.25e-31: 121: 15.96
+	Hs
		433610 LYN_HUMAN (22-526): 0: 554: 70.70		FCG2B_HUMAN (103-287): 6.36e-29: 115: 16.76
+	Hs
		434111 LYN_HUMAN (22-526): 0: 554: 70.70		ROBO1_HUMAN (186-373): 2.25e-23: 104: 13.58
+	Hs
		523003 SRC_HUMAN (1-524): 0: 582: 54.51		MYLK_HUMAN (198-277): 7.87e-10: 62.8: 11.24
+	Hs
		523211 SRC_HUMAN (1-524): 0: 582: 54.51		TUTLB_HUMAN (21-204): 3.23e-09: 60.9: 10.95
+	Hs
		433507 YES_HUMAN (1-524): 0: 570: 56.77		TUTLB_HUMAN (21-204): 3.23e-09: 60.9: 10.95
+	Hs
		434019 LYN_HUMAN (22-526): 0: 554: 70.70		ROBO2_HUMAN (20-105): 1.22e-13: 74.4: 17.02
+	Hs
		434081 LYN_HUMAN (22-526): 0: 554: 70.70		TUTLB_HUMAN (21-204): 3.23e-09: 60.9: 10.95
+	Hs
		433569 LYN_HUMAN (22-526): 0: 554: 70.70		CD22_HUMAN (19-321): 6.02e-09: 59.7: 19.12
+	Dm
		219802 ABL_DROME (5-519): 3.97e-167: 515: 38.10		O44924_DROME (9-105): 1.06e-16: 84: 18.27