HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	22745667, 12029088, 17141806, 11278465, 22641034
Identification Methods	affinity chromatography technology, unspecified method, fluorescent resonance energy transfer, pull down, classical fluorescence spectroscopy, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 443
+	Mm
		403437 SRC_MOUSE (1-524): 0: 585: 55.56		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		522933 SRC_HUMAN (1-524): 0: 582: 54.51		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		411689 LCK_HUMAN (23-526): 0: 581: 64.89		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		980964 YES_MOUSE (1-524): 0: 570: 56.80		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		763394 FYN_MOUSE (22-524): 0: 564: 57.60		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		433330 YES_HUMAN (1-524): 0: 570: 56.77		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		639447 LYN_MOUSE (22-526): 0: 555: 70.70		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		412149 FYN_HUMAN (22-524): 0: 564: 57.79		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		433719 LYN_HUMAN (22-526): 0: 554: 70.70		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (22-524): 0: 552: 55.62		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		789110 FRK_HUMAN (50-520): 1.23e-180: 519: 49.18		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991737 ITK_HUMAN (3-517): 1.06e-168: 492: 33.21		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		986367 BTK_HUMAN (19-519): 1.38e-155: 460: 33.52		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991758 PTK6_HUMAN (72-520): 7.27e-156: 453: 40.00		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		433822 LYN_HUMAN (22-526): 0: 554: 70.70		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Mm
		763412 FYN_MOUSE (22-524): 0: 564: 57.60		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Hs
		1046410 PTK6_HUMAN (72-520): 7.27e-156: 453: 40.00		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Dm
		337713 SRC64_DROME (29-524): 7.5e-172: 498: 44.84		Q9W255_DROME (59-398): 6.04e-96: 295: 32.35
+	Hs
		789069 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Hs
		337484 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33