HitPredict

Interactor 1: RAP1 (P08645)
Ras-related protein Rap1 (EC 3.6.5.2) (Rap1 GTPase) (Ras-like protein 3)
Gene: RAP1

Interactor 2: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	29466741
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0007298 - border follicle cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Dm			1 669
+	Hs
		647864 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		MARK3_HUMAN (11-664): 2.35e-136: 419: 15.26
+	Hs
		647857 RAB2A_HUMAN (4-170): 1.54e-72: 219: 38.10		MARK3_HUMAN (11-664): 2.35e-136: 419: 15.26
+	Hs
		914159 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		MARK2_HUMAN (3-614): 2.18e-132: 410: 15.72
+	Hs
		895142 RAB2A_HUMAN (4-170): 1.54e-72: 219: 38.10		MARK2_HUMAN (3-614): 2.18e-132: 410: 15.72
+	Hs
		682159 RAB2A_HUMAN (4-170): 1.54e-72: 219: 38.10		AKT2_HUMAN (3-339): 4.83e-134: 404: 21.78
+	Hs
		895051 RAB2A_HUMAN (4-170): 1.54e-72: 219: 38.10		KPCT_HUMAN (2-354): 2.28e-130: 402: 20.83
+	Hs
		296405 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		STK10_HUMAN (22-486): 2.03e-116: 373: 32.71
+	Hs
		349893 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		MARK3_HUMAN (11-664): 2.35e-136: 419: 15.26
+	Hs
		897884 RAP1B_HUMAN (1-184): 2.16e-77: 230: 85.95		PAK2_HUMAN (26-317): 5.83e-118: 364: 37.08
+	Hs
		914500 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		STK24_HUMAN (33-316): 5.77e-120: 366: 51.39
+	Hs
		350286 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		MARK2_HUMAN (3-614): 2.18e-132: 410: 15.72
+	Hs
		349916 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		AKT2_HUMAN (3-339): 4.83e-134: 404: 21.78
+	Hs
		296393 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		STK10_HUMAN (22-486): 2.03e-116: 373: 32.71
+	Hs
		1026199 RIT1_HUMAN (2-180): 3.94e-61: 190: 50.00		PAK1_HUMAN (2-317): 1.29e-115: 358: 35.85
+	Hs
		350133 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		PAK2_HUMAN (26-317): 5.83e-118: 364: 37.08
+	Hs
		914488 RB11A_HUMAN (4-179): 6.45e-75: 225: 28.81		M4K5_HUMAN (34-293): 1.19e-68: 241: 44.57
+	Hs
		350320 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		M4K3_HUMAN (38-308): 1.71e-71: 250: 44.25
+	Hs
		486037 RAP2A_HUMAN (1-171): 1.39e-59: 185: 62.79		MINK1_HUMAN (33-320): 1.38e-62: 228: 42.05
+	Hs
		486057 RAP2A_HUMAN (1-171): 1.39e-59: 185: 62.79		TNIK_HUMAN (33-320): 1.39e-62: 228: 41.06
+	Hs
		350342 RASK_HUMAN (1-182): 1.14e-56: 178: 55.50		MINK1_HUMAN (33-320): 1.38e-62: 228: 42.05