Protein: RARA
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)

Gene: RARA
Organism: Homo sapiens
Interactions: 193
UniProt ID: P10276

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520510

RXRA
Retinoic acid receptor RXR-alpha

21

17

Small-scale

0.989

High

520531

RXRG
Retinoic acid receptor RXR-gamma

12

17

Small-scale

0.982

High

520589

NCOA1
Nuclear receptor coactivator 1

14

20

Small-scale

0.981

High

520517

RXRB
Retinoic acid receptor RXR-beta

11

18

Small-scale

0.980

High

520654

NCOA3
Nuclear receptor coactivator 3

9

20

Small-scale

0.968

High

520585

NCOA2
Nuclear receptor coactivator 2

6

20

Small-scale

0.942

High

520495

RARA
Retinoic acid receptor alpha

3

17

Small-scale

0.857

High

520496

RARB
Retinoic acid receptor beta

3

18

Small-scale

0.855

High

520505

RARG
Retinoic acid receptor gamma

3

18

Small-scale

0.855

High

520526

PPARG
Peroxisome proliferator-activated receptor gamma

3

18

Small-scale

0.843

High

520584

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

19

Small-scale

0.793

High

520504

NR2C1
Nuclear receptor subfamily 2 group C member 1

2

17

High-throughput

0.783

High

278215

NCOR1
Nuclear receptor corepressor 1

16

20

Small-scale

0.764

High

520653

NCOR2
Nuclear receptor corepressor 2

11

20

Small-scale

0.756

High

520532

NRIP1
Nuclear receptor-interacting protein 1

7

17

Small-scale

0.747

High

395371

ESR1
Estrogen receptor

2

19

Small-scale

0.735

High

520519

PML
Protein PML

6

20

Small-scale

0.721

High

520586

MED1
Mediator of RNA polymerase II transcription subunit 1

5

20

Small-scale

0.717

High

520581

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.694

High

520578

KLF5
Krueppel-like factor 5

4

20

Small-scale

0.692

High

520545

PRS8
26S proteasome regulatory subunit 8

4

20

Small-scale

0.683

High

520563

UBE3A
Ubiquitin-protein ligase E3A

3

18

Small-scale

0.674

High

180674

TIF1A
Transcription intermediary factor 1-alpha

3

20

Small-scale

0.655

High

464772

SP1
Transcription factor Sp1

3

20

Small-scale

0.651

High

520652

NR2E3
Photoreceptor-specific nuclear receptor

1

18

Small-scale

0.647

High

520501

SRC
Proto-oncogene tyrosine-protein kinase Src

3

9

Small-scale

0.641

High

520613

KAT2B
Histone acetyltransferase KAT2B

3

20

Small-scale

0.640

High

284789

TADA3
Transcriptional adapter 3

2

5

Small-scale

0.636

High

520566

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.636

High

520522

AKT1
RAC-alpha serine/threonine-protein kinase

2

16

Small-scale

0.634

High

520608

TEKT4
Tektin-4

2

2

High-throughput

0.628

High

520645

ITBP2
Integrin beta-1-binding protein 2

2

5

High-throughput

0.626

High

520535

CEBPA
CCAAT/enhancer-binding protein alpha

2

13

Small-scale

0.624

High

520628

TRIB3
Tribbles homolog 3

2

16

Small-scale

0.624

High

388950

FINC
Fibronectin

1

4

High-throughput

0.621

High

520539

NR1H2
Oxysterols receptor LXR-beta

1

17

High-throughput

0.621

High

520516

MK01
Mitogen-activated protein kinase 1

2

12

Small-scale

0.619

High

520650

PKP3
Plakophilin-3

1

20

Small-scale

0.618

High

186157

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

2

4

High-throughput

0.606

High

332479

CCDB1
Cyclin-D1-binding protein 1

2

2

High-throughput

0.606

High

520588

ALX1
ALX homeobox protein 1

2

7

High-throughput

0.606

High

520621

MCRS1
Microspherule protein 1

2

3

High-throughput

0.606

High

520627

BBS4
BBSome complex member BBS4

2

14

High-throughput

0.606

High

520635

PKHF2
Pleckstrin homology domain-containing family F member 2

2

8

High-throughput

0.606

High

520647

PHF8
Histone lysine demethylase PHF8

2

17

Small-scale

0.602

High

520576

TDG
G/T mismatch-specific thymine DNA glycosylase

2

3

Small-scale

0.595

High

325656

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.589

High

520620

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

20

Small-scale

0.586

High

520500

SKI
Ski oncogene

2

2

Small-scale

0.584

High

520572

SQSTM
Sequestosome-1

2

8

Small-scale

0.584

High

520611

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.584

High

520612

CBP
CREB-binding protein

2

20

Small-scale

0.584

High

520625

PRAM
PML-RARA-regulated adapter molecule 1

2

20

Small-scale

0.584

High

520577

SNW1
SNW domain-containing protein 1

1

6

Small-scale

0.581

High

224594

ACTN4
Alpha-actinin-4

1

10

Small-scale

0.578

High

520521

CCND3
G1/S-specific cyclin-D3

1

4

Small-scale

0.573

High

520550

PRAME
Melanoma antigen preferentially expressed in tumors

1

3

Small-scale

0.573

High

520598

MED25
Mediator of RNA polymerase II transcription subunit 25

1

8

Small-scale

0.573

High

486884

PARP1
Poly [ADP-ribose] polymerase 1

2

14

Small-scale

0.571

High

520498

FGFR1
Fibroblast growth factor receptor 1

1

4

Small-scale

0.561

High

520524

S10A3
Protein S100-A3

1

15

Small-scale

0.561

High

520537

CCNH
Cyclin-H

1

15

Small-scale

0.561

High

520557

MDM2
E3 ubiquitin-protein ligase Mdm2

1

7

Small-scale

0.561

High

520558

E2F1
Transcription factor E2F1

1

4

Small-scale

0.561

High

520561

TOP2B
DNA topoisomerase 2-beta

1

9

Small-scale

0.561

High

520615

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

Small-scale

0.561

High

520623

AJUBA
LIM domain-containing protein ajuba

1

20

Small-scale

0.561

High

520595

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

3

Small-scale

0.549

High

221019

HAIR
Lysine-specific demethylase hairless

1

8

High-throughput

0.541

High

192895

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.527

High

520499

SRF
Serum response factor

1

3

Small-scale

0.527

High

520508

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

Small-scale

0.527

High

520551

IRX4
Iroquois-class homeodomain protein IRX-4

1

8

Small-scale

0.527

High

520564

ZBT16
Zinc finger and BTB domain-containing protein 16

1

10

Small-scale

0.527

High

520630

NPAS2
Neuronal PAS domain-containing protein 2

1

20

Small-scale

0.527

High

520631

BAG1
BAG family molecular chaperone regulator 1

1

2

Small-scale

0.527

High

520646

UBQL1
Ubiquilin-1

1

11

Small-scale

0.527

High

520536

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

6

Small-scale

0.515

High

520548

SUMO1
Small ubiquitin-related modifier 1

1

10

Small-scale

0.515

High

520590

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.515

High

520591

NF2L2
Nuclear factor erythroid 2-related factor 2

1

13

Small-scale

0.515

High

520594

ZN423
Zinc finger protein 423

1

13

Small-scale

0.515

High

520580

BECN1
Beclin-1

1

1

High-throughput

0.515

High

520618

OPTN
Optineurin

1

20

High-throughput

0.515

High

520562

ARI5A
AT-rich interactive domain-containing protein 5A

1

20

Small-scale

0.508

High

520592

MK06
Mitogen-activated protein kinase 6

1

15

High-throughput

0.508

High

520512

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

13

Small-scale

0.505

High

520528

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

19

Small-scale

0.505

High

520542

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

Small-scale

0.505

High

520610

AP2C
Transcription factor AP-2 gamma

1

5

Small-scale

0.505

High

132694

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

20

Small-scale

0.501

High

154611

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

Small-scale

0.501

High

188153

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.501

High

332130

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

9

Small-scale

0.501

High

520506

PO2F1
POU domain, class 2, transcription factor 1

1

20

Small-scale

0.501

High

520518

KDM5A
Lysine-specific demethylase 5A

1

16

Small-scale

0.501

High

520543

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

520567

FOXO1
Forkhead box protein O1

1

20

Small-scale

0.501

High

520573

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.501

High

520575

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

520587

TRIP4
Activating signal cointegrator 1

1

6

Small-scale

0.501

High

520597

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

20

Small-scale

0.501

High

520629

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

Small-scale

0.501

High

520552

PRKDC
DNA-dependent protein kinase catalytic subunit

1

12

Small-scale

0.500

High

370524

FOS
Protein c-Fos

1

18

Small-scale

0.484

High

520520

PRDX6
Peroxiredoxin-6

1

12

High-throughput

0.481

High

520529

NKX21
Homeobox protein Nkx-2.1

1

15

Small-scale

0.481

High

520583

TNIP1
TNFAIP3-interacting protein 1

1

20

Small-scale

0.481

High

520622

NRBF2
Nuclear receptor-binding factor 2

1

3

Small-scale

0.481

High

520624

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

520632

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

3

Small-scale

0.481

High

66043

WTIP
Wilms tumor protein 1-interacting protein

1

20

Small-scale

0.479

High

191520

MAGB2
Melanoma-associated antigen B2

1

5

High-throughput

0.479

High

216368

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

Small-scale

0.479

High

287757

MED6
Mediator of RNA polymerase II transcription subunit 6

1

4

Small-scale

0.479

High

300896

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

Small-scale

0.479

High

302344

RNF8
E3 ubiquitin-protein ligase RNF8

1

11

Small-scale

0.479

High

316732

MTA2
Metastasis-associated protein MTA2

1

20

Small-scale

0.479

High

323126

TRI37
E3 ubiquitin-protein ligase TRIM37

1

14

High-throughput

0.479

High

352061

MBD3
Methyl-CpG-binding domain protein 3

1

6

Small-scale

0.479

High

415295

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

446580

NPM
Nucleophosmin

1

3

Small-scale

0.479

High

472420

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

Small-scale

0.479

High

520497

HSP7C
Heat shock cognate 71 kDa protein

1

13

Small-scale

0.479

High

520507

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

20

High-throughput

0.479

High

520509

SPI1
Transcription factor PU.1

1

10

Small-scale

0.479

High

520513

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

9

Small-scale

0.479

High

520514

TNR6
Tumor necrosis factor receptor superfamily member 6

1

5

Small-scale

0.479

High

520515

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

15

Small-scale

0.479

High

520523

CXCR5
C-X-C chemokine receptor type 5

1

7

Small-scale

0.479

High

520525

RFC4
Replication factor C subunit 4

1

6

Small-scale

0.479

High

520527

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

520530

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

520533

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

14

Small-scale

0.479

High

520534

HXA1
Homeobox protein Hox-A1

1

15

Small-scale

0.479

High

520538

ZN131
Zinc finger protein 131

1

11

High-throughput

0.479

High

520540

TERA
Transitional endoplasmic reticulum ATPase

1

10

Small-scale

0.479

High

520541

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

20

Small-scale

0.479

High

520544

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

14

Small-scale

0.479

High

520546

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

Small-scale

0.479

High

520547

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

Small-scale

0.479

High

520549

GTF2I
General transcription factor II-I

1

5

Small-scale

0.479

High

520553

SMAD3
Mothers against decapentaplegic homolog 3

1

11

Small-scale

0.479

High

520554

RBM3
RNA-binding protein 3

1

20

Small-scale

0.479

High

520555

AT8B2
Phospholipid-transporting ATPase ID

1

2

Small-scale

0.479

High

520556

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

Small-scale

0.479

High

520559

RUNX1
Runt-related transcription factor 1

1

2

Small-scale

0.479

High

520560

FABP5
Fatty acid-binding protein 5

1

9

Small-scale

0.479

High

520565

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

Small-scale

0.479

High

520569

TRI32
E3 ubiquitin-protein ligase TRIM32

1

17

Small-scale

0.479

High

520570

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

20

Small-scale

0.479

High

520571

SBP1
Methanethiol oxidase

1

1

Small-scale

0.479

High

520574

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

3

Small-scale

0.479

High

520582

SUZ12
Polycomb protein SUZ12

1

5

Small-scale

0.479

High

520593

H31T
Histone H3.1t

1

5

Small-scale

0.479

High

520599

H2AV
Histone H2A.V

1

12

Small-scale

0.479

High

520600

DSG4
Desmoglein-4

1

8

Small-scale

0.479

High

520602

H2A2B
Histone H2A type 2-B

1

8

Small-scale

0.479

High

520603

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

8

Small-scale

0.479

High

520605

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

520606

HACE1
E3 ubiquitin-protein ligase HACE1

1

11

Small-scale

0.479

High

520607

LRC15
Leucine-rich repeat-containing protein 15

1

1

Small-scale

0.479

High

520609

PSPC1
Paraspeckle component 1

1

20

Small-scale

0.479

High

520616

H2A1C
Histone H2A type 1-C

1

8

Small-scale

0.479

High

520619

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

Small-scale

0.479

High

520626

H2A1A
Histone H2A type 1-A

1

8

Small-scale

0.479

High

520633

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

20

Small-scale

0.479

High

520634

SP130
Histone deacetylase complex subunit SAP130

1

20

Small-scale

0.479

High

520638

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

520639

H2AW
Core histone macro-H2A.2

1

12

Small-scale

0.479

High

520640

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

520641

LIMD1
LIM domain-containing protein 1

1

20

Small-scale

0.479

High

520643

MBD1
Methyl-CpG-binding domain protein 1

1

20

Small-scale

0.479

High

520644

MRT4
mRNA turnover protein 4 homolog

1

5

Small-scale

0.479

High

520648

RUVB1
RuvB-like 1

1

5

Small-scale

0.479

High

520651

CEP83
Centrosomal protein of 83 kDa

1

20

Small-scale

0.479

High

455680

H10
Histone H1.0

1

0

Small-scale

0.458

High

520596

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.458

High

520568

PNRC1
Proline-rich nuclear receptor coactivator 1

1

14

Small-scale

0.457

High

520604

ASXL1
Polycomb group protein ASXL1

1

5

Small-scale

0.457

High

520636

PNRC2
Proline-rich nuclear receptor coactivator 2

1

14

Small-scale

0.457

High

339927

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

5

Small-scale

0.445

High

520502

XRCC6
X-ray repair cross-complementing protein 6

1

15

Small-scale

0.445

High

520503

XRCC5
X-ray repair cross-complementing protein 5

1

15

Small-scale

0.445

High

520511

CD11B
Cyclin-dependent kinase 11B

1

12

Small-scale

0.445

High

520579

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

12

Small-scale

0.445

High

520601

CARM1
Histone-arginine methyltransferase CARM1

1

18

Small-scale

0.445

High

520614

TANK
TRAF family member-associated NF-kappa-B activator

1

1

Small-scale

0.445

High

520637

MED4
Mediator of RNA polymerase II transcription subunit 4

1

4

Small-scale

0.445

High

520642

TBK1
Serine/threonine-protein kinase TBK1

1

16

Small-scale

0.445

High

520649

TR150
Thyroid hormone receptor-associated protein 3

1

20

Small-scale

0.445

High

520617

TMM54
Transmembrane protein 54

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025