HitPredict

Interactor 1: CP3A4 (P08684)
Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
Gene: CYP3A4

Interactor 2: UD2B7 (P16662)
UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)
Gene: UGT2B7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	15611481, 15486048, 19158361, 24366439
Identification Methods	affinity chromatography technology, far western blotting, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0006629 - lipid metabolic process GO:0006805 - xenobiotic metabolic process GO:0008209 - androgen metabolic process GO:0008210 - estrogen metabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 529
+	Hs
		444000 CP3A4_HUMAN (1-503): 0: 575: 100.00		UD16_HUMAN (12-528): 0: 570: 42.55
+	Hs
		444002 CP3A4_HUMAN (1-503): 0: 575: 100.00		UD11_HUMAN (20-528): 0: 567: 43.62
+	Hs
		703523 CP2CI_HUMAN (28-495): 7.4e-154: 449: 23.06		CGT_HUMAN (3-526): 5.04e-161: 470: 31.83