Protein: PJA2
E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)

Gene: PJA2
Organism: Homo sapiens
Interactions: 169
UniProt ID: O43164

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208495

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.906

High

208490

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

208435

PJA2
E3 ubiquitin-protein ligase Praja-2

2

13

Small-scale

0.768

High

168471

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

208482

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

208491

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

208547

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

208592

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

208593

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

20

High-throughput

0.698

High

208549

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.667

High

208568

MOB1A
MOB kinase activator 1A

3

0

Small-scale

0.647

High

208459

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

2

1

Small-scale

0.634

High

208524

RHG36
Rho GTPase-activating protein 36

4

2

High-throughput

0.630

High

208582

UBQL2
Ubiquilin-2

1

9

High-throughput

0.618

High

208504

CUL3
Cullin-3

2

3

High-throughput

0.611

High

208546

SPSB4
SPRY domain-containing SOCS box protein 4

2

6

High-throughput

0.601

High

208548

FAF2
FAS-associated factor 2

2

10

High-throughput

0.601

High

208501

SQSTM
Sequestosome-1

2

3

High-throughput

0.584

High

208455

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

2

Small-scale

0.578

High

208531

KSR1
Kinase suppressor of Ras 1

1

5

Small-scale

0.578

High

208484

RD23A
UV excision repair protein RAD23 homolog A

1

14

High-throughput

0.575

High

208562

IQCN
IQ domain-containing protein N

2

1

High-throughput

0.574

High

208522

KSR2
Kinase suppressor of Ras 2

1

5

Small-scale

0.561

High

208540

BBS1
BBSome complex member BBS1

1

1

Small-scale

0.561

High

208594

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

1

Small-scale

0.561

High

208560

BBS2
BBSome complex member BBS2

1

0

Small-scale

0.549

High

208445

UBXN7
UBX domain-containing protein 7

1

10

High-throughput

0.536

High

208494

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

6

High-throughput

0.536

High

208497

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

208506

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.536

High

208539

ARRD4
Arrestin domain-containing protein 4

1

6

High-throughput

0.536

High

208543

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.536

High

208552

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

10

High-throughput

0.536

High

208565

TXNIP
Thioredoxin-interacting protein

1

6

High-throughput

0.536

High

208567

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

208590

FAF1
FAS-associated factor 1

1

11

High-throughput

0.536

High

208589

MAGD2
Melanoma-associated antigen D2

2

10

High-throughput

0.521

High

208551

DNJC1
DnaJ homolog subfamily C member 1

1

5

High-throughput

0.515

High

208458

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

208557

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

208597

MAGD1
Melanoma-associated antigen D1

1

10

Small-scale

0.481

High

172283

XPO1
Exportin-1

1

3

High-throughput

0.479

High

208438

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

208444

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

208449

LATS1
Serine/threonine-protein kinase LATS1

1

4

Small-scale

0.479

High

208451

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

208460

PGAM1
Phosphoglycerate mutase 1

1

3

Small-scale

0.479

High

208461

VATB2
V-type proton ATPase subunit B, brain isoform

1

2

Small-scale

0.479

High

208462

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

Small-scale

0.479

High

208469

1433S
14-3-3 protein sigma

1

13

High-throughput

0.479

High

208470

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

1

Small-scale

0.479

High

208473

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.479

High

208474

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

Small-scale

0.479

High

208477

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

Small-scale

0.479

High

208478

PRC2A
Protein PRRC2A

1

2

High-throughput

0.479

High

208488

RAB8A
Ras-related protein Rab-8A

1

12

Small-scale

0.479

High

208489

RAB10
Ras-related protein Rab-10

1

12

Small-scale

0.479

High

208492

RAB14
Ras-related protein Rab-14

1

12

Small-scale

0.479

High

208493

1433G
14-3-3 protein gamma

1

13

High-throughput

0.479

High

208496

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.479

High

208498

1433F
14-3-3 protein eta

1

13

High-throughput

0.479

High

208499

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.479

High

208503

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

208507

RHEB
GTP-binding protein Rheb

1

17

Small-scale

0.479

High

208512

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

1

Small-scale

0.479

High

208513

MOONR
Protein moonraker

1

2

High-throughput

0.479

High

208516

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

2

High-throughput

0.479

High

208521

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

208525

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

208528

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

208535

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.479

High

208541

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

208542

TTC8
Tetratricopeptide repeat protein 8

1

1

Small-scale

0.479

High

208553

BBS4
BBSome complex member BBS4

1

1

Small-scale

0.479

High

208555

DNJC2
DnaJ homolog subfamily C member 2

1

4

High-throughput

0.479

High

208559

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

3

Small-scale

0.479

High

208561

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

208569

SP110
Sp110 nuclear body protein

1

2

High-throughput

0.479

High

208572

MYO10
Unconventional myosin-X

1

5

Small-scale

0.479

High

208573

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

208576

TECR
Very-long-chain enoyl-CoA reductase

1

1

Small-scale

0.479

High

208577

HACD3
Very-long-chain

1

2

Small-scale

0.479

High

208581

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

208585

HOOK1
Protein Hook homolog 1

1

7

High-throughput

0.479

High

208586

LEF1
Lymphoid enhancer-binding factor 1

1

3

Small-scale

0.479

High

208588

PRP19
Pre-mRNA-processing factor 19

1

1

High-throughput

0.479

High

208591

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

208595

IRS2
Insulin receptor substrate 2

1

3

Small-scale

0.479

High

144382

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.458

High

208436

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

208441

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

208446

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

Small-scale

0.458

High

208448

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

208479

TSC2
Tuberin

1

0

Small-scale

0.458

High

208483

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

Small-scale

0.458

High

208500

PLD1
Phospholipase D1

1

0

High-throughput

0.458

High

208508

VAS1
V-type proton ATPase subunit S1

1

0

Small-scale

0.458

High

208523

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

208527

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

208533

BBS7
BBSome complex member BBS7

1

0

Small-scale

0.458

High

208534

BBS5
BBSome complex member BBS5

1

0

Small-scale

0.458

High

208575

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.458

High

208578

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

Small-scale

0.458

High

208580

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.458

High

208583

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.458

High

208447

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.445

High

208464

DNJB2
DnaJ homolog subfamily B member 2

1

4

High-throughput

0.445

High

208487

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

208502

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

208518

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

208519

S27A4
Long-chain fatty acid transport protein 4

1

5

High-throughput

0.445

High

208520

S27A1
Long-chain fatty acid transport protein 1

1

5

High-throughput

0.445

High

208532

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

4

High-throughput

0.445

High

208536

SYT2
Synaptotagmin-2

1

1

High-throughput

0.445

High

208538

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

208550

PIWL1
Piwi-like protein 1

1

3

High-throughput

0.445

High

208554

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

208556

SPSB2
SPRY domain-containing SOCS box protein 2

1

6

High-throughput

0.445

High

208558

SYT11
Synaptotagmin-11

1

1

High-throughput

0.445

High

208563

TOLIP
Toll-interacting protein

1

2

High-throughput

0.445

High

208584

RABX5
Rab5 GDP/GTP exchange factor

1

2

High-throughput

0.445

High

208587

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.445

High

208450

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.437

High

208453

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

Small-scale

0.437

High

208454

ALDOC
Fructose-bisphosphate aldolase C

1

1

Small-scale

0.437

High

208456

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

Small-scale

0.437

High

208466

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

Small-scale

0.437

High

208471

TCF7
Transcription factor 7

1

3

Small-scale

0.437

High

208481

CDK9
Cyclin-dependent kinase 9

1

6

Small-scale

0.437

High

208509

RB11B
Ras-related protein Rab-11B

1

11

Small-scale

0.437

High

208514

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

208515

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

1

Small-scale

0.437

High

208517

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

Small-scale

0.437

High

208566

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

208571

TF7L1
Transcription factor 7-like 1

1

2

Small-scale

0.437

High

208468

SSR2
Somatostatin receptor type 2

1

0

High-throughput

0.426

High

208579

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.426

High

208529

SO6A1
Solute carrier organic anion transporter family member 6A1

1

3

High-throughput

0.407

High

208530

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

1

High-throughput

0.407

High

208537

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

2

High-throughput

0.407

High

137563

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

Small-scale

0.249

Low

208437

CCNT1
Cyclin-T1

1

0

Small-scale

0.249

Low

208439

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

Small-scale

0.249

Low

208440

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

Small-scale

0.249

Low

208442

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

Small-scale

0.249

Low

208443

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

Small-scale

0.249

Low

208452

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

Small-scale

0.249

Low

208457

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.249

Low

208463

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

Small-scale

0.249

Low

208465

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

Small-scale

0.249

Low

208467

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

Small-scale

0.249

Low

208472

VATE1
V-type proton ATPase subunit E 1

1

0

Small-scale

0.249

Low

208475

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

Small-scale

0.249

Low

208476

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

Small-scale

0.249

Low

208480

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

Small-scale

0.249

Low

208485

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

Small-scale

0.249

Low

208486

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.249

Low

208505

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

Small-scale

0.249

Low

208510

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

Small-scale

0.249

Low

208511

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

Small-scale

0.249

Low

208526

COX15
Heme A synthase COX15

1

0

Small-scale

0.249

Low

208545

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.249

Low

208564

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

Small-scale

0.249

Low

208570

Q9HCK3
KIAA1569 protein

1

0

Small-scale

0.249

Low

208574

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

208596

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.249

Low

208598

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

Small-scale

0.249

Low

208544

NET5
Netrin-5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025