Interactor 1: FA7 (P08709)
Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
Gene: F7

Interactor 2: TF (P13726)
Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Gene: F3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 0.90 0.865

The method score is based on:

Property Details
Experiments 12787023, 9925787, 8598903, 9414278, 8940045
Identification Methods pull down, x-ray crystallography, enzyme linked immunosorbent assay
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF~Interfer-bind, EGF~Tissue_fac, FXa_inhibition~Tissue_fac, Tissue_fac~Trypsin
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007596 - blood coagulation
GO:0010641 - positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0016485 - protein processing
and 5 others

more...

Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024