Protein: RS5
Small ribosomal subunit protein uS5 (30S ribosomal protein S5)

Gene: RS5, rpsE
Organism: Escherichia coli K-12
Interactions: 192
UniProt ID: P0A7W1

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

494025

RS4
Small ribosomal subunit protein uS4

2

1

High-throughput

0.789

High

493679

RS2
Small ribosomal subunit protein uS2

2

9

High-throughput

0.789

High

494311

RNB
Exoribonuclease 2

2

3

High-throughput

0.633

High

444336

ERA
GTPase Era

2

4

High-throughput

0.628

High

494333

RL3
Large ribosomal subunit protein uL3

2

2

High-throughput

0.628

High

493840

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.625

High

494223

RS8
Small ribosomal subunit protein uS8

1

5

High-throughput

0.625

High

494230

TIG
Trigger factor

3

0

Small-scale

0.622

High

493557

RS19
Small ribosomal subunit protein uS19

2

4

High-throughput

0.612

High

494224

RS9
Small ribosomal subunit protein uS9

2

5

High-throughput

0.612

High

494227

RPOA
DNA-directed RNA polymerase subunit alpha

2

1

High-throughput

0.612

High

494245

CSPG
Cold shock-like protein CspG

2

9

High-throughput

0.612

High

494288

RS1
Small ribosomal subunit protein bS1

2

4

High-throughput

0.612

High

494334

RL4
Large ribosomal subunit protein uL4

2

1

High-throughput

0.612

High

494332

RL2
Large ribosomal subunit protein uL2

2

3

High-throughput

0.611

High

494336

FLAV
Flavodoxin 1

2

0

High-throughput

0.606

High

494272

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.601

High

494228

SSRP
SsrA-binding protein

1

0

High-throughput

0.593

High

493319

RS12
Small ribosomal subunit protein uS12

2

3

High-throughput

0.588

High

494281

NUSA
Transcription termination/antitermination protein NusA

2

0

High-throughput

0.585

High

490981

HSLO
33 kDa chaperonin

2

0

High-throughput

0.563

High

494233

RIMP
Ribosome maturation factor RimP

2

0

High-throughput

0.563

High

382644

RS7
Small ribosomal subunit protein uS7

1

6

High-throughput

0.536

High

395141

UVRD
DNA helicase II

1

1

High-throughput

0.536

High

421101

PNP
Polyribonucleotide nucleotidyltransferase

1

1

High-throughput

0.536

High

444276

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

450090

RF2
Peptide chain release factor RF2

1

3

High-throughput

0.536

High

473254

DNAJ
Chaperone protein DnaJ

1

5

High-throughput

0.536

High

490328

HSLU
ATP-dependent protease ATPase subunit HslU

1

1

High-throughput

0.536

High

491313

HSCA
Chaperone protein HscA

1

4

High-throughput

0.536

High

491418

IF2
Translation initiation factor IF-2

1

8

High-throughput

0.536

High

492148

LEXA
LexA repressor

1

1

High-throughput

0.536

High

492680

RL1
Large ribosomal subunit protein uL1

1

2

High-throughput

0.536

High

494231

YBEY
Endoribonuclease YbeY

1

1

High-throughput

0.536

High

494232

YEEN
Probable transcriptional regulatory protein YeeN

1

1

High-throughput

0.536

High

494250

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

1

High-throughput

0.536

High

494258

RL13
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

494259

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.536

High

494264

GLMU
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase

1

2

High-throughput

0.536

High

494283

UMUD
Protein UmuD

1

1

High-throughput

0.536

High

494287

RS14
Small ribosomal subunit protein uS14

1

1

High-throughput

0.536

High

494291

RL18
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

494294

EFTU1
Elongation factor Tu 1

1

3

High-throughput

0.536

High

494298

SELB
Selenocysteine-specific elongation factor

1

5

High-throughput

0.536

High

494301

ICLR
Transcriptional repressor IclR

1

1

High-throughput

0.536

High

494303

RNR
Ribonuclease R

1

3

High-throughput

0.536

High

494304

RNE
Ribonuclease E

1

1

High-throughput

0.536

High

494305

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

2

High-throughput

0.536

High

494306

MUKB
Chromosome partition protein MukB

1

2

High-throughput

0.536

High

494313

GLMM
Phosphoglucosamine mutase

1

1

High-throughput

0.536

High

494318

AIDB
Putative acyl-CoA dehydrogenase AidB

1

1

High-throughput

0.536

High

494321

CBPA
Curved DNA-binding protein

1

2

High-throughput

0.536

High

494323

RLUB
Ribosomal large subunit pseudouridine synthase B

1

3

High-throughput

0.536

High

494327

OBG
GTPase ObgE/CgtA

1

6

High-throughput

0.536

High

494352

DCYD
D-cysteine desulfhydrase

1

2

High-throughput

0.536

High

494356

TMCA
tRNA(Met) cytidine acetyltransferase TmcA

1

1

High-throughput

0.536

High

365810

RPOD
RNA polymerase sigma factor RpoD

1

0

High-throughput

0.513

High

368788

SYW
Tryptophan--tRNA ligase

1

0

High-throughput

0.513

High

368950

SYGA
Glycine--tRNA ligase alpha subunit

1

0

High-throughput

0.513

High

382550

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.513

High

395070

DNAA
Chromosomal replication initiator protein DnaA

1

0

High-throughput

0.513

High

449984

HIS2
Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.513

High

458777

FDHF
Formate dehydrogenase H

1

0

High-throughput

0.513

High

480531

GRPE
Protein GrpE

1

0

High-throughput

0.513

High

494236

UVRC
UvrABC system protein C

1

0

High-throughput

0.513

High

494240

MATP
Macrodomain Ter protein

1

0

High-throughput

0.513

High

494247

BTUR
Corrinoid adenosyltransferase

1

0

High-throughput

0.513

High

494261

DPS
DNA protection during starvation protein

1

0

High-throughput

0.513

High

494263

DNAB
Replicative DNA helicase DnaB

1

0

High-throughput

0.513

High

494275

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

0

High-throughput

0.513

High

494279

TSAE
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

1

0

High-throughput

0.513

High

494285

RL17
Large ribosomal subunit protein bL17

1

0

High-throughput

0.513

High

494293

RIMK
Ribosomal protein bS6--L-glutamate ligase

1

0

High-throughput

0.513

High

494307

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.513

High

494312

FLIH
Flagellar assembly protein FliH

1

0

High-throughput

0.513

High

494316

YIIS
UPF0381 protein YiiS

1

0

High-throughput

0.513

High

494322

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.513

High

494325

KILR
Killing protein KilR

1

0

High-throughput

0.513

High

494326

NFSB
Oxygen-insensitive NAD(P)H nitroreductase

1

0

High-throughput

0.513

High

494330

TSAC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.513

High

494341

YFCD
Uncharacterized Nudix hydrolase YfcD

1

0

High-throughput

0.513

High

494343

RS21
Small ribosomal subunit protein bS21

1

0

High-throughput

0.513

High

494346

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.513

High

494353

FADI
3-ketoacyl-CoA thiolase FadI

1

0

High-throughput

0.513

High

494276

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.500

High

494295

EFTU2
Elongation factor Tu 2

1

3

High-throughput

0.500

High

494299

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.489

High

494300

SRLR
Glucitol operon repressor

1

1

High-throughput

0.489

High

494310

GREB
Transcription elongation factor GreB

1

1

High-throughput

0.489

High

494324

TCYN
L-cystine transport system ATP-binding protein TcyN

1

1

High-throughput

0.489

High

494328

HRPA
ATP-dependent RNA helicase HrpA

1

1

High-throughput

0.489

High

494349

YNAE
Uncharacterized protein YnaE

1

1

High-throughput

0.489

High

494351

YDFK
Cold shock protein YdfK

1

1

High-throughput

0.489

High

494360

HSCC
Chaperone protein HscC

1

8

High-throughput

0.489

High

490548

EFTS
Elongation factor Ts

1

1

High-throughput

0.484

High

490577

ENO
Enolase

1

3

High-throughput

0.484

High

490801

GREA
Transcription elongation factor GreA

1

1

High-throughput

0.484

High

492061

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.484

High

493195

RS10
Small ribosomal subunit protein uS10

1

5

High-throughput

0.484

High

493350

RS13
Small ribosomal subunit protein uS13

1

5

High-throughput

0.484

High

493458

RS16
Small ribosomal subunit protein bS16

1

2

High-throughput

0.484

High

494238

RHLB
ATP-dependent RNA helicase RhlB

1

6

High-throughput

0.484

High

494239

SYT
Threonine--tRNA ligase

1

4

High-throughput

0.484

High

494241

RPOC
DNA-directed RNA polymerase subunit beta'

1

2

High-throughput

0.484

High

494242

RPOB
DNA-directed RNA polymerase subunit beta

1

4

High-throughput

0.484

High

494243

CSPD
Cold shock-like protein CspD

1

9

High-throughput

0.484

High

494244

CSPE
Cold shock-like protein CspE

1

9

High-throughput

0.484

High

494248

RNG
Ribonuclease G

1

1

High-throughput

0.484

High

494252

DEAD
ATP-dependent RNA helicase DeaD

1

8

High-throughput

0.484

High

494253

FTSE
Cell division ATP-binding protein FtsE

1

1

High-throughput

0.484

High

494254

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

494256

CSPA
Cold shock protein CspA

1

9

High-throughput

0.484

High

494257

CSPC
Cold shock-like protein CspC

1

9

High-throughput

0.484

High

494266

CRP
DNA-binding transcriptional dual regulator CRP

1

2

High-throughput

0.484

High

494267

ALLR
HTH-type transcriptional repressor AllR

1

1

High-throughput

0.484

High

494273

MAP1
Methionine aminopeptidase

1

1

High-throughput

0.484

High

494277

GYRA
DNA gyrase subunit A

1

1

High-throughput

0.484

High

494278

GYRB
DNA gyrase subunit B

1

1

High-throughput

0.484

High

494289

SRP54
Signal recognition particle protein

1

1

High-throughput

0.484

High

494290

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

2

High-throughput

0.484

High

494292

RLME
Ribosomal RNA large subunit methyltransferase E

1

2

High-throughput

0.484

High

494331

RAPA
RNA polymerase-associated protein RapA

1

6

High-throughput

0.484

High

494335

LEPA
Elongation factor 4

1

7

High-throughput

0.484

High

494337

RLMB
23S rRNA

1

2

High-throughput

0.484

High

491586

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.479

High

490368

COAD
Phosphopantetheine adenylyltransferase

1

0

High-throughput

0.464

High

490631

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

High-throughput

0.464

High

490665

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

490700

FIS
DNA-binding protein Fis

1

0

High-throughput

0.464

High

490861

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

490955

IHFB
Integration host factor subunit beta

1

0

High-throughput

0.464

High

491481

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.464

High

491536

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

491924

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

491965

NUSB
Transcription antitermination protein NusB

1

0

High-throughput

0.464

High

492225

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

493592

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.464

High

494225

RNH
Ribonuclease HI

1

0

High-throughput

0.464

High

494229

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

494246

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.464

High

494249

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

494260

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.464

High

494265

HSLR
Heat shock protein 15

1

0

High-throughput

0.464

High

494270

YIBL
Uncharacterized protein YibL

1

0

High-throughput

0.464

High

494282

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.464

High

494284

SPOT
Bifunctional

1

0

High-throughput

0.464

High

494286

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.464

High

494344

NFI
Endonuclease V

1

0

High-throughput

0.464

High

494255

ZNUC
Zinc import ATP-binding protein ZnuC

1

1

High-throughput

0.442

High

494269

FIMB
Type 1 fimbriae regulatory protein FimB

1

1

High-throughput

0.442

High

423986

3MG1
DNA-3-methyladenine glycosylase 1

1

0

High-throughput

0.279

Low

444244

BTUE
Thioredoxin/glutathione peroxidase BtuE

1

0

High-throughput

0.279

Low

490379

CYSC
Adenylyl-sulfate kinase

1

0

High-throughput

0.279

Low

492321

RECO
DNA repair protein RecO

1

0

High-throughput

0.279

Low

494234

NRDR
Transcriptional repressor NrdR

1

0

High-throughput

0.279

Low

494251

NRDG
Anaerobic ribonucleoside-triphosphate reductase-activating protein

1

0

High-throughput

0.279

Low

494268

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

494271

YGIC
Putative acid--amine ligase YgiC

1

0

High-throughput

0.279

Low

494280

NUOE
NADH-quinone oxidoreductase subunit E

1

0

High-throughput

0.279

Low

494296

DAMX
Cell division protein DamX

1

0

High-throughput

0.279

Low

494297

GLPD
Aerobic glycerol-3-phosphate dehydrogenase

1

0

High-throughput

0.279

Low

494302

HYAF
Hydrogenase-1 operon protein HyaF

1

0

High-throughput

0.279

Low

494309

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.279

Low

494314

CBRC
UPF0167 protein CbrC

1

0

High-throughput

0.279

Low

494317

YJBM
Uncharacterized protein YjbM

1

0

High-throughput

0.279

Low

494319

YOHF
Uncharacterized oxidoreductase YohF

1

0

High-throughput

0.279

Low

494320

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.279

Low

494329

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

494339

YDIZ
Uncharacterized protein YdiZ

1

0

High-throughput

0.279

Low

494340

YHCO
Uncharacterized protein YhcO

1

0

High-throughput

0.279

Low

494342

YHAJ
Probable HTH-type transcriptional regulator YhaJ

1

0

High-throughput

0.279

Low

494345

WCAK
Colanic acid biosynthesis protein WcaK

1

0

High-throughput

0.279

Low

494347

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.279

Low

494348

YCGY
Uncharacterized protein YcgY

1

0

High-throughput

0.279

Low

494350

RLHA
23S rRNA 5-hydroxycytidine C2501 synthase

1

0

High-throughput

0.279

Low

494354

MURQ
N-acetylmuramic acid 6-phosphate etherase

1

0

High-throughput

0.279

Low

494355

YFEZ
Inner membrane protein YfeZ

1

0

High-throughput

0.279

Low

494357

PBPC
Penicillin-binding protein 1C

1

0

High-throughput

0.279

Low

494358

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.279

Low

494359

LYSAC
Peptidyl-lysine N-acetyltransferase PatZ

1

0

High-throughput

0.279

Low

494361

YFDK
Uncharacterized protein YfdK

1

0

High-throughput

0.279

Low

494362

TCDA
tRNA threonylcarbamoyladenosine dehydratase

1

0

High-throughput

0.279

Low

479592

YJAB
Peptidyl-lysine N-acetyltransferase YjaB

1

0

High-throughput

0.269

Low

492028

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

494226

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

494235

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

494237

TRMB
tRNA

1

0

High-throughput

0.253

Low

494262

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

494274

DCM
DNA-cytosine methyltransferase

1

0

High-throughput

0.253

Low

494338

YDIH
Uncharacterized protein YdiH

1

0

High-throughput

0.253

Low

494308

YIDC
Membrane protein insertase YidC

1

0

Small-scale

0.249

Low

494315

INTA
Prophage integrase IntA

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025