Protein: MED1
Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1)

Gene: MED1
Organism: Saccharomyces cerevisiae S288C
Interactions: 65
UniProt ID: Q12321

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1015457

MED4
Mediator of RNA polymerase II transcription subunit 4

9

0

Small-scale

0.917

High

704166

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.910

High

693946

MED18
Mediator of RNA polymerase II transcription subunit 18

12

0

Small-scale

0.724

High

994567

MED7
Mediator of RNA polymerase II transcription subunit 7

11

0

Small-scale

0.721

High

748123

MED8
Mediator of RNA polymerase II transcription subunit 8

9

0

Small-scale

0.715

High

581389

MED14
Mediator of RNA polymerase II transcription subunit 14

8

0

Small-scale

0.714

High

693574

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.710

High

859247

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.686

High

693612

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

772531

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.676

High

586347

MED15
Mediator of RNA polymerase II transcription subunit 15

5

0

Small-scale

0.676

High

751482

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.673

High

760604

SSN3
Meiotic mRNA stability protein kinase SSN3

4

0

Small-scale

0.660

High

626047

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.654

High

1015070

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

High-throughput

0.654

High

814174

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.653

High

754291

MED6
Mediator of RNA polymerase II transcription subunit 6

3

0

High-throughput

0.634

High

975997

GCN5
Histone acetyltransferase GCN5

3

0

High-throughput

0.634

High

636005

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.632

High

986573

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.622

High

686874

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

710282

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.585

High

758035

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

High-throughput

0.585

High

1015459

MED11
Mediator of RNA polymerase II transcription subunit 11

2

0

High-throughput

0.585

High

356793

H4
Histone H4

2

0

Small-scale

0.577

High

1015279

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

513230

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

587896

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

676478

XPO1
Exportin-1

1

0

High-throughput

0.513

High

755475

TRA1
Transcription-associated protein 1

1

0

High-throughput

0.513

High

859821

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.513

High

970420

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.513

High

355692

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

902143

H3
Histone H3

1

0

Small-scale

0.480

High

375539

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

407398

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

558328

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

663696

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

715758

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728343

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

751102

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

812168

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

814158

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

978384

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

987858

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

0

High-throughput

0.458

High

1014893

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

1015458

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

492858

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

495322

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

695821

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

979522

PANK
Pantothenate kinase CAB1

1

0

High-throughput

0.438

High

440120

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.426

High

858589

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.426

High

1015259

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

0

High-throughput

0.265

Low

480380

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

544609

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

701143

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

762675

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

811722

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

864472

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

748404

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

361085

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

368515

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

556382

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

785283

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024