Protein: TOP3
DNA topoisomerase 3 (EC 5.6.2.1) (DNA topoisomerase III)

Gene: TOP3, topB
Organism: Escherichia coli K-12
Interactions: 40
UniProt ID: P14294

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0006261 - DNA-templated DNA replication
GO:0006265 - DNA topological change
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444300

TOP1
DNA topoisomerase 1

2

1

High-throughput

0.789

High

571325

RECQ
ATP-dependent DNA helicase RecQ

1

10

High-throughput

0.724

High

571327

HOLD
DNA polymerase III subunit psi

3

0

High-throughput

0.641

High

571326

RECJ
Single-stranded-DNA-specific exonuclease RecJ

2

1

High-throughput

0.640

High

367428

ILVI
Acetolactate synthase isozyme 3 large subunit

2

1

High-throughput

0.611

High

499064

DBHA
DNA-binding protein HU-alpha

2

2

High-throughput

0.588

High

500391

GCL
Glyoxylate carboligase

2

1

High-throughput

0.588

High

571328

HOLC
DNA polymerase III subunit chi

1

1

High-throughput

0.561

High

492618

RL19
Large ribosomal subunit protein bL19

2

1

High-throughput

0.537

High

493924

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.537

High

420206

RECD
RecBCD enzyme subunit RecD

1

0

High-throughput

0.513

High

500788

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.513

High

449855

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

3

High-throughput

0.489

High

494299

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.489

High

497021

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.489

High

571329

YEJF
Uncharacterized ABC transporter ATP-binding protein YejF

1

2

High-throughput

0.489

High

571332

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.489

High

571336

HSCC
Chaperone protein HscC

1

3

High-throughput

0.489

High

494549

RNH
Ribonuclease HI

1

1

High-throughput

0.484

High

501525

SSB
Single-stranded DNA-binding protein

1

3

High-throughput

0.445

High

492946

RL28
Large ribosomal subunit protein bL28

1

1

High-throughput

0.442

High

493098

RL33
Large ribosomal subunit protein bL33

1

1

High-throughput

0.442

High

497504

RL13
Large ribosomal subunit protein uL13

1

2

High-throughput

0.442

High

571335

RL22
Large ribosomal subunit protein uL22

1

1

High-throughput

0.442

High

498218

ATPA
ATP synthase subunit alpha

1

1

High-throughput

0.437

High

571330

FRLR
Probable fructoselysine utilization operon transcriptional repressor

2

0

High-throughput

0.318

High

571331

ABGT
p-aminobenzoyl-glutamate transport protein

2

0

High-throughput

0.318

High

500605

GHXP
Guanine/hypoxanthine permease GhxP

2

0

High-throughput

0.307

High

501323

RS14
Small ribosomal subunit protein uS14

2

0

High-throughput

0.307

High

571334

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.307

High

493766

RS2
Small ribosomal subunit protein uS2

1

0

High-throughput

0.279

Low

553307

MOEB
Molybdopterin-synthase adenylyltransferase

1

0

High-throughput

0.279

Low

571337

LSRK
Autoinducer-2 kinase

1

0

High-throughput

0.279

Low

492389

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.253

Low

492515

RL7
Large ribosomal subunit protein bL12

1

0

High-throughput

0.253

Low

493040

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.253

Low

493493

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.253

Low

498481

CCMB
Heme exporter protein B

1

0

High-throughput

0.253

Low

501233

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.253

Low

571333

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.253

Low


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Last updated: 11Aug2025