HitPredict

Interactor 1: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11094073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~fn3, SH2~fn3, C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2347 Hs			1 847
+	Dm
		526798 7LESS_DROME (154-2288): 0: 1688: 23.77		GRAP_DROME (672-843): 3.76e-15: 77: 31.25
+	Hs
		411523 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Hs
		855777 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		411288 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		435676 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		FGD5_HUMAN (1-614): 5.83e-77: 275: 13.26
+	Hs
		279867 EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43		TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29
+	Hs
		580937 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		562635 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580965 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		872610 EPHB1_HUMAN (1380-2304): 0: 609: 18.67		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		665574 EPHB2_HUMAN (1381-2344): 0: 601: 18.74		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		872621 EPHB2_MOUSE (1381-2304): 0: 598: 19.31		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		872630 EPHA4_HUMAN (1385-2321): 0: 594: 19.52		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		665389 EPHA3_HUMAN (1383-2242): 0: 590: 20.98		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		872422 EPHA5_HUMAN (1360-2290): 0: 586: 19.28		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924590 EPHA7_HUMAN (1385-2313): 1.98e-180: 581: 18.43		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		411292 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		665467 EPHA8_HUMAN (1383-2242): 1.9e-173: 562: 18.61		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		411352 INSR_HUMAN (1424-2308): 7.33e-167: 555: 23.13		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		435602 IGF1R_HUMAN (1442-2307): 3.63e-161: 538: 23.25		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39