HitPredict

Interactor 1: FGF2 (P09038)
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Gene: FGF2

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 9174056, 21693575, 7520751, 8609172, 15096041, 11786412, 18199118, 15548653, 19696444, 10748122, 8692946, 14505356, 1709094, 16829530, 19627396, 8868466, 1697263, 10950949, 35384245, 36736316 and 10 others

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Identification Methods affinity chromatography technology, pull down, unspecified method, proximity labelling technology, cross-linking study, biochemical, coimmunoprecipitation, x-ray crystallography, surface plasmon resonance, scintillation proximity assay and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set
Common GO terms GO:0001759 - organ induction
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0008201 - heparin binding
GO:0008284 - positive regulation of cell population proliferation
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 288
Hs

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Last updated: 15 Jul 2024