HitPredict

Interactor 1: FGF2 (P09038)
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Gene: FGF2

Interactor 2: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 18199118, 28514442, 1697263, 33961781, 35384245, 36736316, 10950949, 11121055, 11390973, 26267536, 17981115, 9700203, 10830168
Identification Methods unspecified method, affinity chromatography technology, pull down, biochemical, x-ray crystallography, nuclear magnetic resonance, enzyme linked immunosorbent assay, anti tag coimmunoprecipitation, blue native page, surface plasmon resonance
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set, FGF~Ig_3
Common GO terms GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0008201 - heparin binding
GO:0008284 - positive regulation of cell population proliferation
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024