HitPredict

Interactor 1: SCR (P09077)
Homeotic protein Sex combs reduced
Gene: SCR

Interactor 2: EMS (P18488)
Homeotic protein empty spiracles
Gene: EMS

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	25869471
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 417 Dm			1 497
+	Dm
		447327 SCR_DROME (1-417): 2.07e-59: 201: 100.00		HMPB_DROME (352-472): 5.99e-30: 126: 33.86
+	Dm
		577201 UBX_DROME (178-385): 2.21e-30: 122: 32.86		EMS_DROME (1-497): 3.92e-57: 199: 100.00
+	Hs
		658621 MSX1_HUMAN (211-398): 2.04e-44: 158: 26.73		HXC8_HUMAN (223-459): 5.24e-29: 116: 16.74
+	Hs
		567821 HXA1_HUMAN (158-396): 3.22e-29: 118: 27.46		HXB9_HUMAN (180-456): 1.54e-40: 148: 24.20
+	Hs
		538767 HXB1_HUMAN (160-406): 1.44e-35: 134: 27.80		HXD1_HUMAN (241-453): 1.28e-33: 131: 23.94
+	Dm
		611153 TIN_DROME (93-403): 2.42e-41: 153: 19.20		UBX_DROME (245-452): 2.14e-26: 112: 19.43
+	Dm
		950087 Q9VSC2_DROME (77-387): 6.98e-41: 153: 21.34		UBX_DROME (245-452): 2.14e-26: 112: 19.43
+	Dm
		950014 UBX_DROME (178-385): 2.21e-30: 122: 32.86		Q7KS72_DROME (315-465): 1.18e-37: 142: 31.61
+	Dm
		428860 DFD_DROME (304-389): 4.71e-36: 141: 66.29		UBX_DROME (245-452): 2.14e-26: 112: 19.43
+	Hs
		538750 HXB1_HUMAN (160-406): 1.44e-35: 134: 27.80		HXA1_HUMAN (213-464): 2.2e-29: 119: 21.65
+	Hs
		678775 HXD3_HUMAN (156-401): 2.7e-35: 136: 28.57		HXC8_HUMAN (223-459): 5.24e-29: 116: 16.74
+	Hs
		446864 HXD4_HUMAN (205-389): 8.42e-36: 133: 41.71		HXA5_HUMAN (280-460): 1.55e-29: 118: 24.47
+	Dm
		367190 ANTP_DROME (95-404): 6.77e-36: 137: 36.05		UBX_DROME (245-452): 2.14e-26: 112: 19.43
+	Hs
		678889 MEOX1_HUMAN (225-398): 1.34e-35: 133: 31.61		HXC8_HUMAN (223-459): 5.24e-29: 116: 16.74
+	Dm
		950100 UBX_DROME (178-385): 2.21e-30: 122: 32.86		Q9W1H7_DROME (360-497): 3.93e-32: 124: 18.84
+	Hs
		446885 HXB5_HUMAN (179-395): 2.73e-34: 130: 33.64		HXC4_HUMAN (346-451): 7.82e-26: 108: 33.96
+	Hs
		829796 HXA1_HUMAN (158-396): 3.22e-29: 118: 27.46		HXA1_HUMAN (213-464): 2.2e-29: 119: 21.65
+	Hs
		174008 SHOX_HUMAN (324-383): 1.28e-29: 118: 38.33		SHOX_HUMAN (381-472): 7.76e-29: 117: 32.61
+	Dm
		1229480 Q9VSC2_DROME (77-387): 6.98e-41: 153: 21.34		Q8MZ02_DROME (390-453): 7.65e-10: 62.8: 54.69