HitPredict

Interactor 1: GROA (P09341)
Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]
Gene: CXCL1

Interactor 2: MMP12 (P39900)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 470
+	Hs
		587770 CXCL2_HUMAN (1-107): 2.32e-35: 118: 89.72		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		587787 CXCL3_HUMAN (1-107): 3.61e-33: 112: 86.92		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		364043 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		764724 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		764727 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		372731 CXCL2_HUMAN (1-107): 2.32e-35: 118: 89.72		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		364034 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		500671 CXCL2_MOUSE (9-107): 6.01e-34: 114: 62.63		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		372733 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		714631 CXCL3_MOUSE (9-107): 1.89e-32: 110: 57.58		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		372737 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		372724 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		612139 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		MMP8_HUMAN (13-470): 0: 599: 47.16
+	Mm
		522396 GROA_MOUSE (33-103): 3.05e-28: 100: 67.61		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Mm
		714630 CXCL5_MOUSE (18-105): 6.63e-26: 95.1: 48.89		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		540414 CXCL2_HUMAN (1-107): 2.32e-35: 118: 89.72		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		364037 CXCL7_HUMAN (25-106): 1.11e-29: 104: 51.22		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		540419 CXCL5_HUMAN (30-104): 2.01e-27: 98.6: 48.00		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		540420 CXCL6_HUMAN (30-104): 9.47e-26: 94.4: 42.67		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		486175 IL8_HUMAN (38-107): 2.37e-24: 90.1: 43.66		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77