HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: SMT3 (Q12306)
Ubiquitin-like protein SMT3
Gene: SMT3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.645

Property	Details
Experiments	11283351, 15590687, 18719252
Identification Methods	two hybrid pooling approach, affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1428 Sc			1 101
+	Hs
		542417 TOP2A_HUMAN (2-1427): 0: 1481: 41.18		SUMO2_HUMAN (9-98): 2.33e-36: 120: 42.86
+	Hs
		964232 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		SUMO2_HUMAN (9-98): 2.33e-36: 120: 42.86
+	Hs
		991298 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		SUMO1_HUMAN (1-98): 2.09e-33: 112: 44.44
+	Rn
		1136008 Q14TE9_RAT (2-1420): 0: 1461: 40.51		SUMO3_RAT (9-98): 1.05e-35: 119: 43.96