HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: HXD3 (P31249)
Homeobox protein Hox-D3 (Homeobox protein Hox-4A)
Gene: HOXD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	8890171
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 432
+	Hs
		175758 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		MEOX2_HUMAN (105-256): 4.89e-39: 144: 30.92
+	Hs
		175781 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		Q6FHY5_HUMAN (105-256): 4.77e-39: 144: 30.92
+	Hs
		449517 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXB3_HUMAN (17-432): 6.23e-32: 127: 41.67
+	Hs
		449608 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		LHX2_HUMAN (68-333): 2.46e-31: 125: 15.17
+	Hs
		449682 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		PO5F1_HUMAN (48-326): 1.6e-31: 125: 13.58
+	Hs
		449787 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		LHX4_HUMAN (158-420): 6.68e-31: 124: 13.24
+	Hs
		449499 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXC6_HUMAN (40-253): 2.12e-30: 118: 26.17
+	Hs
		643330 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PO5F1_HUMAN (48-326): 1.6e-31: 125: 13.58
+	Hs
		175759 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		LHX2_HUMAN (68-333): 2.46e-31: 125: 15.17
+	Hs
		643381 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		LHX4_HUMAN (158-420): 6.68e-31: 124: 13.24
+	Hs
		595592 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		HXA5_HUMAN (31-266): 1.37e-38: 142: 31.56
+	Hs
		818455 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ALX4_HUMAN (20-365): 1.89e-32: 128: 19.23
+	Hs
		817938 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PO5F1_HUMAN (48-326): 1.6e-31: 125: 13.58
+	Hs
		818493 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		LHX9_HUMAN (66-319): 3.6e-31: 125: 17.38
+	Hs
		617325 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		ZFHX4_HUMAN (131-285): 1.64e-12: 72: 15.48
+	Dm
		668309 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		ABDA_DROME (189-268): 4.75e-16: 82: 56.25
+	Dm
		115535 M9PFG6_DROME (7-95): 5.32e-26: 105: 21.35		ABDA_DROME (189-268): 4.75e-16: 82: 56.25
+	Dm
		114546 M9PCZ7_DROME (3-84): 4.91e-25: 104: 23.17		ABDA_DROME (189-268): 4.75e-16: 82: 56.25
+	Hs
		1199928 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		ZFHX4_HUMAN (131-285): 1.64e-12: 72: 15.48
+	Hs
		818205 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ZFHX4_HUMAN (131-285): 1.64e-12: 72: 15.48