HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: CROCC (Q5TZA2)
Rootletin (Ciliary rootlet coiled-coil protein)
Gene: CROCC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0015629 - actin cytoskeleton
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 2017
+	Hs
		418974 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		CROCC_HUMAN (1-2017): 8.31e-143: 494: 100.00
+	Hs
		451201 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MYH9_HUMAN (1042-2007): 1.53e-40: 167: 13.90
+	Hs
		418895 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MYH9_HUMAN (1042-2007): 1.53e-40: 167: 13.90
+	Hs
		434354 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MYH9_HUMAN (1042-2007): 1.53e-40: 167: 13.90
+	Hs
		110796 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		MYH9_HUMAN (1042-2007): 1.53e-40: 167: 13.90
+	Hs
		724765 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		MYH9_HUMAN (1042-2007): 1.53e-40: 167: 13.90
+	Dm
		828657 TPM4_DROME (1-281): 7.27e-35: 133: 55.52		Q9VCD1_DROME (771-2017): 2.73e-36: 153: 10.86
+	Hs
		148289 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		CTRO_HUMAN (546-1275): 5.6e-09: 63.9: 21.01
+	Hs
		148661 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		CTRO_HUMAN (546-1275): 5.6e-09: 63.9: 21.01