HitPredict

Interactor 1: WNT2 (P09544)
Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP)
Gene: WNT2

Interactor 2: WLS (Q5T9L3)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Gene: WLS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MIG-14_Wnt-bd~wnt
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 541
+	Mm
		568285 WNT3_MOUSE (27-349): 5.05e-158: 449: 44.91		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		881860 WNT3A_HUMAN (27-349): 7.21e-155: 440: 43.71		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		782089 WNT5A_HUMAN (12-349): 6.84e-153: 437: 47.34		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		611175 WNT5A_MOUSE (12-349): 1.59e-152: 435: 47.34		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		881881 WNT4_HUMAN (12-349): 3.51e-151: 431: 46.53		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135438 WNT5B_HUMAN (24-349): 9.93e-149: 425: 47.80		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		881899 WNT7B_HUMAN (37-349): 4.31e-147: 420: 48.90		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135451 WNT16_HUMAN (10-349): 2.89e-145: 417: 41.36		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		135861 WNT7A_HUMAN (37-349): 1.5e-145: 417: 47.02		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		382254 WNT1_MOUSE (23-348): 2.46e-143: 412: 40.58		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		384072 WNT1_HUMAN (23-348): 2.23e-143: 412: 40.58		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135437 WNT8A_HUMAN (64-355): 1.24e-122: 358: 40.07		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158076 WNT9B_HUMAN (32-349): 3.83e-119: 350: 39.45		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158068 WNT9A_HUMAN (32-350): 2.72e-117: 345: 36.86		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135420 WNT8B_HUMAN (64-350): 1.95e-112: 333: 40.94		WLS_HUMAN (1-541): 0: 811: 100.00
+	Dm
		658764 WNT2_DROME (33-349): 2.85e-123: 360: 41.74		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		776060 WNT4_DROME (41-349): 1.95e-104: 318: 33.96		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		658776 WNT5_DROME (41-178): 2.57e-50: 182: 39.13		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		452324 WNTG_DROME (246-348): 2.93e-39: 146: 43.69		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		1279555 Q9VM26_DROME (15-150): 2.66e-30: 121: 29.93		WLS_DROME (1-535): 0: 642: 40.82