HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	16456542
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016324 - apical plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1106 Hs			1 337
+	Mm
		404019 PGFRB_MOUSE (1-1106): 0: 801: 85.44		NHRF2_MOUSE (1-337): 1.39e-77: 242: 91.99
+	Hs
		153861 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		153870 PGFRA_HUMAN (3-1106): 0: 716: 42.48		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		280015 KIT_HUMAN (3-1003): 0: 601: 29.99		MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16
+	Hs
		169176 MUSK_HUMAN (120-966): 1.11e-145: 460: 16.48		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1021503 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1049964 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1020166 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		1081620 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Hs
		153863 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		507995 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		507970 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		153881 UFO_HUMAN (5-330): 1.39e-13: 77.6: 13.03		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		280018 FGFR3_HUMAN (1-313): 7.09e-52: 198: 10.66		MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16
+	Hs
		607966 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		674412 UFO_HUMAN (5-330): 1.39e-13: 77.6: 13.03		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		674422 UFO_HUMAN (5-330): 1.39e-13: 77.6: 13.03		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37