HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12177062, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 665
+	Hs
		499283 KIT_HUMAN (3-1003): 0: 601: 29.99		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		452344 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208979 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		452342 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		499225 KIT_HUMAN (3-1003): 0: 601: 29.99		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Mm
		403541 KIT_MOUSE (24-1004): 0: 603: 31.01		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		499253 KIT_HUMAN (3-1003): 0: 601: 29.99		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		275165 KIT_HUMAN (3-1003): 0: 601: 29.99		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Mm
		292679 KIT_MOUSE (24-1004): 0: 603: 31.01		GRAP2_MOUSE (1-55): 2.15e-16: 82.8: 30.91
+	Hs
		208982 KIT_HUMAN (3-1003): 0: 601: 29.99		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		403536 KIT_MOUSE (24-1004): 0: 603: 31.01		VAV_MOUSE (84-158): 6.98e-13: 74: 27.63
+	Hs
		738192 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Ce
		666210 EGL15_CAEEL (11-1064): 1.41e-153: 486: 16.68		SEM5_CAEEL (2-167): 1.56e-29: 118: 21.08
+	Hs
		924527 MERTK_HUMAN (120-967): 1.8e-135: 437: 16.54		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557705 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		548695 MERTK_HUMAN (120-967): 1.8e-135: 437: 16.54		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		209063 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77