HitPredict

Interactor 1: RU2A (P09661)
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')
Gene: SNRPA1

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_9~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071005 - U2-type precatalytic spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 95
+	Hs
		1204016 DAA11_HUMAN (1-247): 3.37e-46: 162: 21.34		LSM2_HUMAN (1-95): 4.21e-38: 124: 100.00
+	Hs
		453791 RU2A_HUMAN (1-255): 9.82e-54: 175: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		453793 RU2A_HUMAN (1-255): 9.82e-54: 175: 100.00		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		453789 RU2A_HUMAN (1-255): 9.82e-54: 175: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sp
		193912 RU2A_SCHPO (2-230): 1.23e-38: 136: 41.60		SMD1_SCHPO (1-95): 3.62e-28: 100: 31.58
+	Dm
		218366 RU2A_DROME (1-232): 1.29e-39: 139: 53.33		SMD3_DROME (2-74): 2.73e-23: 88.4: 23.29
+	Sp
		1358054 RU2A_SCHPO (2-230): 1.23e-38: 136: 41.60		SMD3_SCHPO (2-74): 1.26e-24: 90.4: 27.40
+	Dm
		1097024 RU2A_DROME (1-232): 1.29e-39: 139: 53.33		RUXF_DROME (3-84): 2.1e-23: 86.9: 26.83
+	Sc
		767843 RU2A_YEAST (14-227): 2.09e-31: 117: 24.07		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	Sc
		795430 RU2A_YEAST (14-227): 2.09e-31: 117: 24.07		SMD3_YEAST (2-91): 3.42e-22: 84.2: 18.89