Protein: LSM4
LSM complex subunit LSM4 (Like-SM protein 4)

Gene: LSM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 171
UniProt ID: P40070

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

818014

LSM1
LSM1-LSM7 complex subunit LSM1

11

20

Small-scale

0.979

High

678685

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

10

2

Small-scale

0.976

High

818039

LSM3
LSM complex subunit LSM3

9

20

Small-scale

0.974

High

818015

LSM8
LSM2-LSM8 complex subunit LSM8

8

20

Small-scale

0.974

High

818057

LSM6
LSM complex subunit LSM6

7

8

Small-scale

0.972

High

795874

LSM2
LSM complex subunit LSM2

6

14

Small-scale

0.955

High

818034

LSM7
LSM complex subunit LSM7

6

20

Small-scale

0.955

High

818003

LSM5
LSM complex subunit LSM5

4

3

Small-scale

0.909

High

817114

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

6

Small-scale

0.894

High

818056

SMD2
Small nuclear ribonucleoprotein Sm D2

3

5

High-throughput

0.858

High

818047

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

3

3

High-throughput

0.855

High

818004

RUXG
Small nuclear ribonucleoprotein G

3

20

High-throughput

0.830

High

818001

LSM4
LSM complex subunit LSM4

2

4

Small-scale

0.800

High

751745

PRP8
Pre-mRNA-splicing factor 8

2

3

High-throughput

0.789

High

780180

SN114
Pre-mRNA-splicing factor SNU114

2

6

High-throughput

0.789

High

818012

SMD3
Small nuclear ribonucleoprotein Sm D3

2

15

Small-scale

0.789

High

818020

SART3
U4/U6 snRNA-associated-splicing factor PRP24

2

1

Small-scale

0.754

High

744117

BRR2
Pre-mRNA-splicing helicase BRR2

7

10

Small-scale

0.741

High

645434

XRN1
5'-3' exoribonuclease 1

5

1

High-throughput

0.716

High

394603

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.699

High

625099

PRP9
Pre-mRNA-splicing factor PRP9

1

2

High-throughput

0.691

High

818045

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.691

High

812045

DHH1
ATP-dependent RNA helicase DHH1

3

2

High-throughput

0.669

High

818018

PRP31
Pre-mRNA-processing factor 31

3

4

High-throughput

0.662

High

818073

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

2

Small-scale

0.656

High

818076

DCP1
mRNA-decapping enzyme subunit 1

3

0

Small-scale

0.638

High

430862

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.618

High

818038

RUXF
Small nuclear ribonucleoprotein F

1

8

High-throughput

0.618

High

818067

RU2A
U2 small nuclear ribonucleoprotein A'

1

5

High-throughput

0.618

High

625015

PRP6
Pre-mRNA-splicing factor 6

2

7

High-throughput

0.611

High

627851

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

8

High-throughput

0.611

High

815132

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

1

Small-scale

0.611

High

818061

DIB1
Spliceosomal protein DIB1

2

2

High-throughput

0.611

High

545042

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.601

High

818026

DCP2
m7GpppN-mRNA hydrolase

2

0

High-throughput

0.594

High

444531

DED1
ATP-dependent RNA helicase DED1

2

0

Small-scale

0.588

High

818031

GIS2
Zinc finger protein GIS2

2

0

High-throughput

0.587

High

721623

RENT1
ATP-dependent helicase NAM7

2

1

Small-scale

0.586

High

403528

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

0

Small-scale

0.585

High

679736

CDC48
Cell division control protein 48

2

0

High-throughput

0.569

High

818025

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.561

High

664300

SSD1
Protein SSD1

1

1

High-throughput

0.541

High

672105

PUF4
Pumilio homology domain family member 4

1

1

High-throughput

0.541

High

676935

SRO9
RNA-binding protein SRO9

1

4

High-throughput

0.541

High

740938

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

4

High-throughput

0.541

High

809460

MPT5
Suppressor protein MPT5

1

1

High-throughput

0.541

High

818013

SCD6
Protein SCD6

1

1

High-throughput

0.541

High

721975

XPO1
Exportin-1

1

3

High-throughput

0.536

High

739248

PRP21
Pre-mRNA-splicing factor PRP21

1

3

High-throughput

0.536

High

818019

SF3B1
U2 snRNP component HSH155

1

3

High-throughput

0.536

High

818021

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.536

High

818053

RSE1
Pre-mRNA-splicing factor RSE1

1

3

High-throughput

0.536

High

818072

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.536

High

678967

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.518

High

776586

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.518

High

816650

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.518

High

818030

CAF40
Protein CAF40

1

0

High-throughput

0.518

High

818029

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

818040

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.513

High

818041

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

649969

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.508

High

818011

GZF3
Protein GZF3

1

1

High-throughput

0.508

High

818036

NST1
Stress response protein NST1

1

1

High-throughput

0.508

High

818062

PRP11
Pre-mRNA-splicing factor PRP11

1

3

High-throughput

0.508

High

818065

SLK19
Kinetochore protein SLK19

1

3

High-throughput

0.508

High

818009

COPB
Coatomer subunit beta

1

1

High-throughput

0.489

High

614826

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.486

High

743504

F26
Fructose-2,6-bisphosphatase

1

0

High-throughput

0.486

High

807763

CSK2C
Casein kinase II subunit beta'

1

0

High-throughput

0.486

High

818043

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.486

High

818048

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.486

High

818049

PPN1
Endopolyphosphatase

1

0

High-throughput

0.486

High

818050

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.486

High

818054

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.486

High

818064

YL032
KH domain-containing protein YLL032C

1

0

High-throughput

0.486

High

806287

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.481

High

818075

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.481

High

818023

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

436429

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

518037

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.479

High

594393

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

707220

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

738856

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

809257

MET30
F-box protein MET30

1

4

High-throughput

0.479

High

815300

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

1

Small-scale

0.479

High

818042

NOP3
Serine/arginine

1

3

Small-scale

0.479

High

818066

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.479

High

818069

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

503497

RS28B
Small ribosomal subunit protein eS28B

1

1

High-throughput

0.464

High

818027

COPA
Coatomer subunit alpha

1

2

High-throughput

0.464

High

743391

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.460

High

453956

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

579475

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

677415

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

818007

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

818037

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

818051

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.458

High

818058

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.458

High

818063

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

818068

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

818070

RPN5
26S proteasome regulatory subunit RPN5

1

0

Small-scale

0.458

High

818071

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.458

High

760653

WHI3
Protein WHI3

1

6

High-throughput

0.457

High

524088

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526808

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

531757

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

676731

GBP2
Serine/arginine

1

2

High-throughput

0.445

High

739148

PRP19
Pre-mRNA-processing factor 19

1

9

Small-scale

0.445

High

751965

LHP1
La protein homolog

1

3

High-throughput

0.445

High

792073

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.445

High

818017

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

818077

RS28A
Small ribosomal subunit protein eS28A

1

1

High-throughput

0.439

High

584234

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

1

High-throughput

0.437

High

783924

RM07
Large ribosomal subunit protein uL5m

1

1

High-throughput

0.437

High

812339

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

818052

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.437

High

358231

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

818010

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

818005

JEM1
DnaJ-like chaperone JEM1

1

1

High-throughput

0.407

High

736556

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.282

High

556571

STE6
Alpha-factor-transporting ATPase

1

0

High-throughput

0.265

Low

755212

STE13
Dipeptidyl aminopeptidase A

1

0

High-throughput

0.265

Low

808272

STN1
Protein STN1

1

0

High-throughput

0.265

Low

818002

DSE1
Protein DSE1

1

0

High-throughput

0.265

Low

818006

YIC9
Uncharacterized protein YIL029C

1

0

High-throughput

0.265

Low

818016

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.265

Low

818060

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.265

Low

554506

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

554612

RM02
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.249

Low

569498

RM31
Large ribosomal subunit protein mL60

1

0

High-throughput

0.249

Low

628159

RM33
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.249

Low

647917

RM08
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.249

Low

647986

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.249

Low

657448

RM25
Large ribosomal subunit protein mL59

1

0

High-throughput

0.249

Low

672542

RM32
Large ribosomal subunit protein bL32m

1

0

High-throughput

0.249

Low

678183

IMG1
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.249

Low

678598

IMG2
Large ribosomal subunit protein mL49

1

0

High-throughput

0.249

Low

725725

RM09
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.249

Low

736260

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

736344

RM49
Large ribosomal subunit protein mL61

1

0

High-throughput

0.249

Low

743762

RML2
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.249

Low

778214

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

783790

RM03
Large ribosomal subunit protein mL44

1

0

High-throughput

0.249

Low

783855

RM04
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.249

Low

783982

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

784047

RM11
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.249

Low

784099

RM15
Large ribosomal subunit protein mL57

1

0

High-throughput

0.249

Low

784162

RM24
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.249

Low

784212

RM27
Large ribosomal subunit protein mL41

1

0

High-throughput

0.249

Low

784253

RM28
Large ribosomal subunit protein mL40

1

0

High-throughput

0.249

Low

784314

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

784380

RM36
Large ribosomal subunit protein bL31m

1

0

High-throughput

0.249

Low

784423

RM37
Large ribosomal subunit protein mL54

1

0

High-throughput

0.249

Low

784451

RM39
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.249

Low

784484

RM40
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.249

Low

792611

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

818008

RN49
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.249

Low

818022

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

818024

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

818028

RM50
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.249

Low

818032

RM19
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.249

Low

818033

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low

818035

RN35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.249

Low

818044

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.249

Low

818046

ATP25
ATPase synthesis protein 25, mitochondrial

1

0

High-throughput

0.249

Low

818055

RM51
Large ribosomal subunit protein mL43

1

0

High-throughput

0.249

Low

818059

RM35
Large ribosomal subunit protein mL38

1

0

High-throughput

0.249

Low

818074

RM23
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.249

Low

150219

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.238

Low

747396

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025