Protein: IF4E
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)

Gene: IF4E, CDC33
Organism: Saccharomyces cerevisiae S288C
Interactions: 188
UniProt ID: P07260

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0003743 - translation initiation factor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

453953

IF4F1
Eukaryotic initiation factor 4F subunit p150

25

18

Small-scale

0.993

High

453954

IF4F2
Eukaryotic initiation factor 4F subunit p130

8

18

Small-scale

0.971

High

453888

CAF20
Cap-associated protein CAF20

17

0

Small-scale

0.935

High

403304

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

8

2

Small-scale

0.745

High

453934

EAP1
Protein EAP1

9

0

Small-scale

0.719

High

444390

DED1
ATP-dependent RNA helicase DED1

3

2

Small-scale

0.680

High

453925

NCBP1
Nuclear cap-binding protein complex subunit 1

3

1

High-throughput

0.667

High

453882

IF4A
ATP-dependent RNA helicase eIF4A

3

5

Small-scale

0.662

High

454017

SLF1
Protein SLF1

3

4

Small-scale

0.650

High

453895

XRN1
5'-3' exoribonuclease 1

3

0

Small-scale

0.634

High

453883

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.633

High

453885

SSB1
Ribosome-associated molecular chaperone SSB1

3

2

High-throughput

0.633

High

453881

SSBP1
Single-stranded nucleic acid-binding protein

2

5

High-throughput

0.628

High

453923

LHP1
La protein homolog

2

3

High-throughput

0.628

High

453940

HEK2
Heterogeneous nuclear rnp K-like protein 2

2

1

High-throughput

0.621

High

434696

RS3
Small ribosomal subunit protein uS3

3

0

Small-scale

0.613

High

453904

GBP2
Serine/arginine

2

5

Small-scale

0.611

High

392015

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.606

High

453918

TOR2
Serine/threonine-protein kinase TOR2

2

2

Small-scale

0.602

High

453894

DPOE
DNA polymerase epsilon catalytic subunit A

2

0

High-throughput

0.602

High

454010

LUC7
Protein LUC7

2

0

High-throughput

0.595

High

453980

LSM7
LSM complex subunit LSM7

2

3

High-throughput

0.588

High

453935

GBLP
Small ribosomal subunit protein RACK1

2

4

Small-scale

0.584

High

453949

DHH1
ATP-dependent RNA helicase DHH1

2

7

Small-scale

0.584

High

454014

NCBP2
Nuclear cap-binding protein subunit 2

2

1

Small-scale

0.584

High

453928

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.576

High

453971

PSP2
Protein PSP2

2

0

Small-scale

0.576

High

453973

ROM2
RHO1 GDP-GTP exchange protein 2

2

0

High-throughput

0.576

High

453875

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.571

High

453921

SMY2
Protein SMY2

2

0

Small-scale

0.559

High

453917

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.552

High

453957

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

453877

RS4A
Small ribosomal subunit protein eS4A

2

0

Small-scale

0.547

High

453887

AAKG
5'-AMP-activated protein kinase subunit gamma

1

2

High-throughput

0.536

High

453892

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

1

High-throughput

0.536

High

453937

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

1

High-throughput

0.536

High

453948

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.536

High

453969

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.536

High

453970

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.536

High

453977

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

453979

CBK1
Serine/threonine-protein kinase CBK1

1

4

High-throughput

0.536

High

453985

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

453992

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.528

High

367464

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.513

High

448115

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

453870

CYAA
Adenylate cyclase

1

0

High-throughput

0.513

High

453893

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.513

High

453922

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

453952

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.513

High

453955

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.513

High

453958

RAD26
DNA repair and recombination protein RAD26

1

0

High-throughput

0.513

High

453963

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.513

High

453967

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

453997

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

454003

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.513

High

454005

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.513

High

454022

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

453926

HSL1
Probable serine/threonine-protein kinase HSL1

1

1

High-throughput

0.501

High

453927

TOR1
Serine/threonine-protein kinase TOR1

1

2

Small-scale

0.501

High

453964

SCD6
Protein SCD6

1

2

Small-scale

0.501

High

453994

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.501

High

358934

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.500

High

453871

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.500

High

453891

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.500

High

453998

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.493

High

453933

YPT53
GTP-binding protein YPT53

1

2

High-throughput

0.489

High

453996

WDR59
Maintenance of telomere capping protein 5

1

4

High-throughput

0.489

High

454000

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.489

High

454018

RTK1
Probable serine/threonine-protein kinase RTK1

1

3

High-throughput

0.489

High

454024

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.489

High

453900

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

453988

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

0

High-throughput

0.480

High

408269

GAL1
Galactokinase

1

0

High-throughput

0.479

High

439187

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

448600

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.479

High

453869

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.479

High

453911

URA7
CTP synthase 1

1

0

High-throughput

0.479

High

364234

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.479

High

438354

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

Small-scale

0.479

High

438561

SC160
Protein SCP160

1

1

High-throughput

0.479

High

453868

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.479

High

453896

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.479

High

453901

SSD1
Protein SSD1

1

2

High-throughput

0.479

High

453905

SRO9
RNA-binding protein SRO9

1

4

Small-scale

0.479

High

453915

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

Small-scale

0.479

High

453920

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

453932

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

453941

LSM2
LSM complex subunit LSM2

1

1

Small-scale

0.479

High

453943

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

453945

HRB1
Serine/arginine

1

4

Small-scale

0.479

High

453966

LSM1
LSM1-LSM7 complex subunit LSM1

1

3

Small-scale

0.479

High

453976

CDH1
APC/C activator protein CDH1

1

3

Small-scale

0.479

High

453982

LSM3
LSM complex subunit LSM3

1

2

Small-scale

0.479

High

453984

NAM8
Protein NAM8

1

2

High-throughput

0.479

High

453990

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

454023

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

453974

MLC1
Myosin light chain 1

1

1

High-throughput

0.470

High

453961

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.460

High

381793

H4
Histone H4

1

0

High-throughput

0.458

High

435669

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

436261

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

453866

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.458

High

453872

TBA1
Tubulin alpha-1 chain

1

0

Small-scale

0.458

High

453879

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

453890

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

453898

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

453902

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

453903

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

453906

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

453909

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

453912

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

453913

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

453916

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

453919

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

453929

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

453930

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

453931

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

453939

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

453942

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

453944

SDO1L
Restriction of telomere capping protein 3

1

0

Small-scale

0.458

High

453956

LSM4
LSM complex subunit LSM4

1

0

Small-scale

0.458

High

453959

TM108
Protein TMA108

1

0

High-throughput

0.458

High

453962

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

453968

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

453975

PNC1
Nicotinamidase

1

0

High-throughput

0.458

High

453978

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

453983

H3
Histone H3

1

0

High-throughput

0.458

High

453986

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

453993

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

Small-scale

0.458

High

453995

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

454001

PAL1
Protein PAL1

1

0

High-throughput

0.458

High

454002

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

454006

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

454013

VTS1
RNA-binding protein VTS1

1

0

Small-scale

0.458

High

454016

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

454020

BBP
Branchpoint-bridging protein

1

0

Small-scale

0.458

High

454021

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

454025

SUS1
SAGA complex subunit SUS1

1

0

Small-scale

0.458

High

453991

PKH3
Serine/threonine-protein kinase PKH3

1

2

High-throughput

0.457

High

359402

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.457

High

405000

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

453960

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.457

High

394113

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

453884

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

453897

TRX1
Thioredoxin-1

1

1

Small-scale

0.445

High

453899

TRX2
Thioredoxin-2

1

1

Small-scale

0.445

High

453908

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.445

High

453936

CDC27
Anaphase-promoting complex subunit CDC27

1

1

High-throughput

0.445

High

453873

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

453907

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

453946

HAL5
Serine/threonine-protein kinase HAL5

1

1

High-throughput

0.437

High

453989

YMZ2
WD repeat-containing protein YMR102C

1

3

High-throughput

0.437

High

454004

RGA2
Rho-type GTPase-activating protein 2

1

2

High-throughput

0.437

High

432441

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.426

High

453348

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

453886

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.426

High

453914

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.426

High

453950

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

453972

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.426

High

453987

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

454009

BRE1
E3 ubiquitin-protein ligase BRE1

1

0

High-throughput

0.426

High

454019

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.426

High

453965

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

453878

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.305

High

435484

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.279

Low

453947

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

453999

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

454011

NOP6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

453889

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.269

Low

454008

BSP1
F-actin capping regulator BSP1

1

0

High-throughput

0.269

Low

408539

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

409841

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433347

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

441605

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

453867

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

453874

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

453876

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

453880

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

453910

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

453924

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

453938

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

453951

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

453981

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

454007

GPN3
GPN-loop GTPase 3

1

0

Small-scale

0.249

Low

454012

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

454015

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

427016

FUR4
Uracil permease

1

0

High-throughput

0.232

Low

432948

RL6B
Large ribosomal subunit protein eL6B

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025