HitPredict - High confidence protein-protein interactions

Interactor 1: RPAC1 (P07703)
DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40)
Gene: RPC40

Interactor 2: RPAB3 (P20436)
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (ABC14.4) (ABC14.5) (DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide)
Gene: RPB8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	17937913, 11805826, 37968396, 16429126
Identification Methods	mass spectrometry studies of complexes, tandem affinity purification, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	RNA_pol_L~RNA_pol_Rpb8
Common GO terms	GO:0003677 - DNA binding GO:0003899 - DNA-directed RNA polymerase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex and 11 others more... GO:0005736 - RNA polymerase I complex GO:0006360 - transcription by RNA polymerase I GO:0006361 - transcription initiation at RNA polymerase I promoter GO:0006362 - transcription elongation by RNA polymerase I GO:0006363 - termination of RNA polymerase I transcription GO:0006383 - transcription by RNA polymerase III GO:0006384 - transcription initiation at RNA polymerase III promoter GO:0006386 - termination of RNA polymerase III transcription GO:0042254 - ribosome biogenesis GO:0042790 - nucleolar large rRNA transcription by RNA polymerase I GO:0042797 - tRNA transcription by RNA polymerase III
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	335
Sc

1	146

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Last updated: 11Aug2025