Interactor 1: DLDH (P0A9P0)
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)
Gene: lpdA

Interactor 2: DLDH (P0A9P0)
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)
Gene: lpdA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments unassigned104, 16858726
Identification Methods comigration in non denaturing gel electrophoresis, blue native page
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pyr_redox_2~Pyr_redox_2, Pyr_redox_2~Pyr_redox_dim, Pyr_redox_dim~Pyr_redox_dim
Common GO terms GO:0004148 - dihydrolipoyl dehydrogenase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005960 - glycine cleavage complex
and 13 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 474
Ec

1 474
+ Dm
+ Dm
+ Hs
+ Rn
+ Ec
+ Hs
+ At
+ Sc
+ Sp
+ Sc
+ Mp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024