Protein: SENP6
Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)

Gene: SENP6
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9GZR1

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

964449

SUMO2
Small ubiquitin-related modifier 2

2

20

Small-scale

0.778

High

1428457

PRP19
Pre-mRNA-processing factor 19

4

8

High-throughput

0.699

High

991421

SUMO1
Small ubiquitin-related modifier 1

1

20

Small-scale

0.647

High

386205

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

8

High-throughput

0.640

High

508585

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.618

High

1116582

FHL3
Four and a half LIM domains protein 3

2

0

High-throughput

0.585

High

714407

PML
Protein PML

2

7

High-throughput

0.584

High

1428459

RUVB2
RuvB-like 2

2

2

Small-scale

0.584

High

465037

SP1
Transcription factor Sp1

1

2

High-throughput

0.561

High

1428458

EXO1
Exonuclease 1

1

0

Small-scale

0.537

High

1370361

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

1092489

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.518

High

373096

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

414576

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

487727

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

769119

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

855514

ATRX
Transcriptional regulator ATRX

1

3

Small-scale

0.479

High

883680

CENPA
Histone H3-like centromeric protein A

1

6

High-throughput

0.479

High

981075

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

998782

H31
Histone H3.1

1

6

High-throughput

0.479

High

1017191

H33
Histone H3.3

1

6

High-throughput

0.479

High

1048091

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.479

High

1097546

CBX3
Chromobox protein homolog 3

1

8

High-throughput

0.479

High

1313413

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1314405

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1338946

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

1340805

COP1
E3 ubiquitin-protein ligase COP1

1

9

High-throughput

0.479

High

1371279

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.479

High

1387549

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1404375

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.479

High

1428451

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1428453

NLE1
Notchless protein homolog 1

1

5

High-throughput

0.479

High

1428455

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1428456

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

1428460

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

516781

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

1289608

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1428452

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.458

High

1428454

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1428450

ZDBF2
DBF4-type zinc finger-containing protein 2

2

0

High-throughput

0.319

High

572754

PA2GA
Phospholipase A2, membrane associated

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025