HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: NR2C2 (P49116)
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Gene: NR2C2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30463901, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Hormone_recep
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 596
+	Hs
		461265 HS90A_HUMAN (1-724): 0: 1069: 85.25		NR2C2_HUMAN (1-596): 0: 527: 100.00
+	Hs
		573382 ENPL_HUMAN (3-693): 0: 914: 46.44		NR2C2_HUMAN (1-596): 0: 527: 100.00
+	Hs
		468006 HS90B_HUMAN (1-724): 0: 1083: 100.00		VDR_HUMAN (95-583): 4.48e-80: 260: 18.86
+	Hs
		282917 HS90B_HUMAN (1-724): 0: 1083: 100.00		NR1I2_HUMAN (94-580): 1.57e-73: 243: 18.33
+	Hs
		282916 HS90A_HUMAN (1-724): 0: 1069: 85.25		NR1I2_HUMAN (94-580): 1.57e-73: 243: 18.33
+	Hs
		137524 ENPL_HUMAN (3-693): 0: 914: 46.44		NR5A2_HUMAN (68-585): 9.79e-112: 346: 22.01
+	Hs
		573342 ENPL_HUMAN (3-693): 0: 914: 46.44		RXRB_HUMAN (73-289): 3.84e-46: 172: 31.00