Protein: NR1I2
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)

Gene: NR1I2
Organism: Homo sapiens
Interactions: 49
UniProt ID: O75469

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282942

NCOA1
Nuclear receptor coactivator 1

10

20

Small-scale

0.971

High

282921

RXRA
Retinoic acid receptor RXR-alpha

4

20

Small-scale

0.881

High

282927

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.817

High

282924

RXRB
Retinoic acid receptor RXR-beta

2

20

Small-scale

0.757

High

282916

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

282954

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

4

20

Small-scale

0.698

High

282940

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

Small-scale

0.680

High

282917

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

282957

NCOR2
Nuclear receptor corepressor 2

3

20

Small-scale

0.658

High

137520

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.621

High

282929

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.621

High

282941

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.621

High

282958

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.621

High

282952

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

7

Small-scale

0.573

High

282914

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.561

High

282919

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.561

High

282928

YAP1
Transcriptional coactivator YAP1

1

14

Small-scale

0.561

High

282947

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

17

Small-scale

0.561

High

278189

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.552

High

282918

FGR
Tyrosine-protein kinase Fgr

1

14

High-throughput

0.541

High

282937

MK07
Mitogen-activated protein kinase 7

1

15

High-throughput

0.541

High

282939

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

20

High-throughput

0.541

High

282948

AP2C
Transcription factor AP-2 gamma

1

8

High-throughput

0.541

High

282938

NCOA6
Nuclear receptor coactivator 6

1

20

Small-scale

0.527

High

163674

TCRG1
Transcription elongation regulator 1

1

16

High-throughput

0.515

High

282922

KS6B1
Ribosomal protein S6 kinase beta-1

1

18

Small-scale

0.501

High

282923

PIT1
Pituitary-specific positive transcription factor 1

1

20

Small-scale

0.501

High

282933

UBC9
SUMO-conjugating enzyme UBC9

1

15

Small-scale

0.501

High

282935

MDM2
E3 ubiquitin-protein ligase Mdm2

1

8

Small-scale

0.501

High

282936

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

282955

DNM3L
DNA

1

7

Small-scale

0.501

High

282943

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.494

High

282913

TADA3
Transcriptional adapter 3

1

4

Small-scale

0.481

High

282931

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.481

High

282953

CHM1A
Charged multivesicular body protein 1a

1

2

High-throughput

0.481

High

282915

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

282920

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

Small-scale

0.479

High

282925

EF1D
Elongation factor 1-delta

1

4

High-throughput

0.479

High

282930

CEBPA
CCAAT/enhancer-binding protein alpha

1

19

Small-scale

0.479

High

282932

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

9

Small-scale

0.479

High

282944

DDB1
DNA damage-binding protein 1

1

5

Small-scale

0.479

High

282945

RBBP7
Histone-binding protein RBBP7

1

20

Small-scale

0.479

High

282949

DNJC7
DnaJ homolog subfamily C member 7

1

11

Small-scale

0.479

High

282950

ANM1
Protein arginine N-methyltransferase 1

1

20

Small-scale

0.479

High

282956

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

282946

S13A5
Na(+)/citrate cotransporter

1

0

Small-scale

0.458

High

282926

ACTN2
Alpha-actinin-2

1

7

High-throughput

0.439

High

282951

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.439

High

282934

NUCB2
Nucleobindin-2

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025