Protein: VDR
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)

Gene: VDR
Organism: Homo sapiens
Interactions: 129
UniProt ID: P11473

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000902 - cell morphogenesis
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

543456

RXRA
Retinoic acid receptor RXR-alpha

27

20

Small-scale

0.992

High

543515

NCOA1
Nuclear receptor coactivator 1

10

20

Small-scale

0.972

High

543476

RXRG
Retinoic acid receptor RXR-gamma

5

20

Small-scale

0.916

High

543556

NCOA3
Nuclear receptor coactivator 3

5

20

Small-scale

0.914

High

543511

NCOA2
Nuclear receptor coactivator 2

5

20

Small-scale

0.911

High

543450

VDR
Vitamin D3 receptor

3

20

Small-scale

0.834

High

543465

RXRB
Retinoic acid receptor RXR-beta

2

20

High-throughput

0.754

High

543513

MED1
Mediator of RNA polymerase II transcription subunit 1

8

20

Small-scale

0.750

High

543471

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.724

High

278220

NCOR1
Nuclear receptor corepressor 1

5

20

Small-scale

0.711

High

543451

SRC
Proto-oncogene tyrosine-protein kinase Src

4

14

Small-scale

0.680

High

543500

SQSTM
Sequestosome-1

3

8

Small-scale

0.674

High

239532

MED14
Mediator of RNA polymerase II transcription subunit 14

3

20

Small-scale

0.667

High

543525

MED12
Mediator of RNA polymerase II transcription subunit 12

3

20

Small-scale

0.664

High

543469

CTNB1
Catenin beta-1

1

20

Small-scale

0.646

High

543503

SNW1
SNW domain-containing protein 1

2

6

Small-scale

0.642

High

543468

CCND3
G1/S-specific cyclin-D3

2

8

Small-scale

0.633

High

543470

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

9

Small-scale

0.631

High

221023

HAIR
Lysine-specific demethylase hairless

2

7

Small-scale

0.629

High

371029

MYC
Myc proto-oncogene protein

2

7

Small-scale

0.624

High

543496

ZBT16
Zinc finger and BTB domain-containing protein 16

2

4

Small-scale

0.624

High

543533

NLRP3
NACHT, LRR and PYD domains-containing protein 3

2

5

Small-scale

0.624

High

543483

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.621

High

543508

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

High-throughput

0.621

High

543473

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.618

High

543487

SMAD3
Mothers against decapentaplegic homolog 3

2

11

Small-scale

0.606

High

543493

OTUD4
OTU domain-containing protein 4

2

4

High-throughput

0.606

High

543524

CBP
CREB-binding protein

2

20

Small-scale

0.602

High

543550

MED23
Mediator of RNA polymerase II transcription subunit 23

2

2

Small-scale

0.595

High

543555

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.594

High

282351

MED24
Mediator of RNA polymerase II transcription subunit 24

2

6

Small-scale

0.584

High

287759

MED6
Mediator of RNA polymerase II transcription subunit 6

2

3

Small-scale

0.584

High

543478

CEBPA
CCAAT/enhancer-binding protein alpha

2

18

Small-scale

0.584

High

543548

MED13
Mediator of RNA polymerase II transcription subunit 13

2

3

Small-scale

0.584

High

543553

MED16
Mediator of RNA polymerase II transcription subunit 16

2

2

Small-scale

0.584

High

543486

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.584

High

543530

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

468006

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.575

High

543480

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.573

High

543512

PCH2
Pachytene checkpoint protein 2 homolog

1

20

High-throughput

0.573

High

543498

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.571

High

219687

FOXO3
Forkhead box protein O3

1

20

Small-scale

0.561

High

224599

ACTN4
Alpha-actinin-4

1

8

Small-scale

0.561

High

240597

PRKN
E3 ubiquitin-protein ligase parkin

1

16

Small-scale

0.561

High

543474

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

19

Small-scale

0.561

High

543491

RUNX1
Runt-related transcription factor 1

1

4

Small-scale

0.561

High

543497

MTG8
Protein CBFA2T1

1

2

Small-scale

0.561

High

543527

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

18

Small-scale

0.561

High

413081

P53
Cellular tumor antigen p53

1

8

Small-scale

0.554

High

543535

KS6C1
Ribosomal protein S6 kinase delta-1

2

18

High-throughput

0.553

High

543506

NCOA6
Nuclear receptor coactivator 6

1

20

Small-scale

0.552

High

543509

TAF11
Transcription initiation factor TFIID subunit 11

1

1

Small-scale

0.552

High

543536

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.550

High

543466

TPP2
Tripeptidyl-peptidase 2

1

1

High-throughput

0.536

High

543499

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.536

High

543507

STK38
Serine/threonine-protein kinase 38

1

15

High-throughput

0.536

High

543523

GLMP
Glycosylated lysosomal membrane protein

1

2

High-throughput

0.536

High

543538

AKAP9
A-kinase anchor protein 9

1

16

High-throughput

0.536

High

543539

KLDC3
Kelch domain-containing protein 3

1

6

High-throughput

0.536

High

543540

SETD2
Histone-lysine N-methyltransferase SETD2

1

20

High-throughput

0.536

High

543546

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

18

High-throughput

0.536

High

543551

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

2

High-throughput

0.536

High

543461

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

7

Small-scale

0.534

High

543485

CSN2
COP9 signalosome complex subunit 2

1

8

Small-scale

0.527

High

543505

NCOA4
Nuclear receptor coactivator 4

1

3

Small-scale

0.527

High

543545

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.513

High

325661

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.501

High

370528

FOS
Protein c-Fos

1

16

Small-scale

0.501

High

429202

JUN
Transcription factor Jun

1

18

Small-scale

0.501

High

442561

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.501

High

543454

PO2F1
POU domain, class 2, transcription factor 1

1

20

Small-scale

0.501

High

543459

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

Small-scale

0.501

High

543462

MK03
Mitogen-activated protein kinase 3

1

9

Small-scale

0.501

High

543463

PIT1
Pituitary-specific positive transcription factor 1

1

20

Small-scale

0.501

High

543464

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.501

High

543467

KDM5A
Lysine-specific demethylase 5A

1

15

Small-scale

0.501

High

543502

TDG
G/T mismatch-specific thymine DNA glycosylase

1

4

Small-scale

0.501

High

543531

LCOR
Ligand-dependent corepressor

1

3

Small-scale

0.501

High

543554

GRIP1
Glutamate receptor-interacting protein 1

1

17

Small-scale

0.501

High

543549

LEF1
Lymphoid enhancer-binding factor 1

1

18

Small-scale

0.500

High

472266

CFAH
Complement factor H

1

2

High-throughput

0.494

High

543534

SNX18
Sorting nexin-18

1

4

High-throughput

0.489

High

543477

NRIP1
Nuclear receptor-interacting protein 1

1

18

High-throughput

0.481

High

543484

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.481

High

543514

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

1

High-throughput

0.481

High

543519

ANR11
Ankyrin repeat domain-containing protein 11

1

13

High-throughput

0.481

High

543521

CXXC5
CXXC-type zinc finger protein 5

1

3

High-throughput

0.481

High

543522

CLASR
CLK4-associating serine/arginine rich protein

1

3

High-throughput

0.481

High

543532

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

543541

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.481

High

543542

MMRN2
Multimerin-2

1

11

High-throughput

0.481

High

543547

RNF14
E3 ubiquitin-protein ligase RNF14

1

10

Small-scale

0.481

High

219468

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

Small-scale

0.479

High

543452

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

Small-scale

0.479

High

543457

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.479

High

543458

CD11B
Cyclin-dependent kinase 11B

1

15

Small-scale

0.479

High

543460

ARBK1
Beta-adrenergic receptor kinase 1

1

19

Small-scale

0.479

High

543472

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.479

High

543481

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

Small-scale

0.479

High

543488

FOXO4
Forkhead box protein O4

1

20

Small-scale

0.479

High

543489

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

20

Small-scale

0.479

High

543490

MDM2
E3 ubiquitin-protein ligase Mdm2

1

7

Small-scale

0.479

High

543492

RELB
Transcription factor RelB

1

20

Small-scale

0.479

High

543494

TF65
Transcription factor p65

1

20

Small-scale

0.479

High

543495

MAD1
Max dimerization protein 1

1

5

Small-scale

0.479

High

543501

MED21
Mediator of RNA polymerase II transcription subunit 21

1

3

Small-scale

0.479

High

543504

CUL3
Cullin-3

1

12

High-throughput

0.479

High

543510

TAF7
Transcription initiation factor TFIID subunit 7

1

1

Small-scale

0.479

High

543516

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

543537

BAG1
BAG family molecular chaperone regulator 1

1

3

Small-scale

0.479

High

543543

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

5

Small-scale

0.479

High

543544

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

Small-scale

0.479

High

543552

TR150
Thyroid hormone receptor-associated protein 3

1

17

Small-scale

0.479

High

543557

X5D778
Ankyrin repeat domain 11 isoform A

1

20

High-throughput

0.470

High

183124

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.460

High

543529

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.460

High

341193

VATG2
V-type proton ATPase subunit G 2

1

0

High-throughput

0.458

High

536383

HSP7C
Heat shock cognate 71 kDa protein

1

16

High-throughput

0.445

High

543455

EGR1
Early growth response protein 1

1

6

Small-scale

0.445

High

543517

MYOME
Myomegalin

1

13

High-throughput

0.445

High

543453

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.439

High

543482

AFF1
AF4/FMR2 family member 1

1

20

Small-scale

0.437

High

543475

PCP
Lysosomal Pro-X carboxypeptidase

1

0

High-throughput

0.282

High

543520

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

543518

GOLM2
Protein GOLM2

1

0

High-throughput

0.251

Low

543526

NKD2
Protein naked cuticle homolog 2

1

0

High-throughput

0.251

Low

543479

CAMP
Cathelicidin antimicrobial peptide

1

0

Small-scale

0.249

Low

543528

CNRP1
CB1 cannabinoid receptor-interacting protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025