HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: KAT5 (Q92993)
Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein)
Gene: KAT5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	27153538, 28242625, 33961781, 35271311, 22467210, 24463511
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071392 - cellular response to estradiol stimulus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 513
+	Mm
		470234 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		KAT5_MOUSE (1-513): 0: 852: 99.81
+	Mm
		1111884 H2AV_MOUSE (1-127): 2.06e-60: 183: 98.43		KAT5_MOUSE (1-513): 0: 852: 99.81
+	Hs
		391828 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		KAT5_HUMAN (1-513): 0: 852: 100.00
+	Hs
		555576 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		KAT5_HUMAN (1-513): 0: 852: 100.00
+	Dm
		446320 H2AV_DROME (1-125): 2.57e-60: 183: 96.00		TIP60_DROME (7-512): 0: 709: 57.60
+	Sp
		293417 H2AZ_SCHPO (18-119): 1.91e-46: 148: 78.43		ESA1_SCHPO (22-504): 0: 581: 40.83
+	Hs
		391906 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		KAT8_HUMAN (162-504): 3.51e-168: 485: 46.67
+	Hs
		555648 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		KAT8_HUMAN (162-504): 3.51e-168: 485: 46.67
+	Hs
		309651 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		KAT7_HUMAN (111-504): 1.86e-157: 463: 40.30
+	Hs
		309706 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		KAT7_HUMAN (111-504): 1.86e-157: 463: 40.30
+	Hs
		309643 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		KAT7_HUMAN (111-504): 1.86e-157: 463: 40.30
+	Hs
		470113 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		KAT6A_HUMAN (70-504): 1.5e-138: 442: 37.23
+	Sc
		710460 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		SAS3_YEAST (208-504): 1.23e-123: 382: 40.66
+	Sc
		996191 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		ESA1_YEAST (21-103): 6e-11: 66.3: 38.10